Autosomal dominant polycystic kidney disease (ADPKD) is the most common renal
monogenic disorder. It is characterized by progressive, bilateral renal cystic expansion …

Introduction Tolvaptan, a treatment for autosomal dominant polycystic kidney disease
(ADPKD), inhibits vasopressin V2 receptor signaling, which causes aquaretic adverse …

Ciliopathies form a group of inherited disorders sharing several clinical manifestations
because of abnormal cilia formation or function, and few treatments have been successful …

The synthesis of nonpeptide orally bioavailable vasopressin antagonists devoid of agonistic
activity (vaptans) has made possible the selective blockade of vasopressin receptor …

Autosomal dominant polycystic kidney disease (ADPKD) is the most common monogenetic
inherited kidney disease characterized by renal progressive fluid-filled cysts and interstitial …

MicroRNAs are involved in the regulation of the autophagy and proliferation in several
diseases. This study aims to verify the role of miR-25-3p in the proliferation and autophagy …

Polycystic kidney disease (PKD) encompasses a group of genetic disorders that are
common causes of renal failure. The two classic forms of PKD are autosomal recessive …

Abstract Polycystin 2 (PC2 or TRPP1, formerly TRPP2) is a calcium-permeant Transient
Receptor Potential (TRP) cation channel expressed primarily on the endoplasmic reticulum …

Autosomal dominant polycystic kidney disease (ADPKD) is an inherited disorder
characterized by the progressive growth of renal cysts that, over time, destroy the …

Background Autosomal dominant polycystic kidney disease (ADPKD) is characterized by
numerous cysts originating from renal tubules and is associated with significant tubular …