The major forms of diabetes are characterized by pancreatic islet β-cell dysfunction and
decreased β-cell numbers, raising hope for cell replacement therapy. Although human islet …

Activin was discovered in the 1980's as a gonadal protein that stimulated FSH release from
pituitary gonadotropes and was thought of as a reproductive hormone. In the ensuing …

While it could be said that regenerative medicine is what this journal publishes, that would
be cyclical. It could also be claimed that most people interested in the field have a good …

Human pluripotent stem cells represent a potentially unlimited source of functional
pancreatic endocrine lineage cells. Here we report a highly efficient approach to induce …

The generation of insulin-producing β-cells from human pluripotent stem cells is dependent
on efficient endoderm induction and appropriate patterning and specification of this germ …

Transplantation of human embryonic stem cells (hESC) into immune-deficient mice leads to
the formation of differentiated tumors comprising all three germ layers, resembling …

Directed differentiation of human embryonic stem cells (ESCs) into cardiovascular cells
provides a model for studying molecular mechanisms of human cardiovascular …

Human induced pluripotent stem (hiPS) cells have potential uses for drug discovery and cell
therapy, including generation of pancreatic β-cells for diabetes research and treatment. In …

Development of biomaterials to control the fate of stem cells is important for stem cell based
regeneration of bone tissue. The objective of this study is to develop functionalized …

After the initial discovery of activins as important regulators of reproduction, novel and
diverse roles have been unraveled for them. Activins are expressed in various tissues and …