Increased cell migration and plasticity in Nrf2-deficient cancer cell lines
G Rachakonda, KR Sekhar, D Jowhar, PC Samson… - Oncogene, 2010 - nature.com
Abstract Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) expression is deregulated in many
cancers. Genetic and biochemical approaches coupled with functional assays in cultured …
cancers. Genetic and biochemical approaches coupled with functional assays in cultured …
Antisense glutaminase inhibition decreases glutathione antioxidant capacity and increases apoptosis in Ehrlich ascitic tumour cells
Glutamine is an essential amino acid in cancer cells and is required for the growth of many
other cell types. Glutaminase activity is positively correlated with malignancy in tumours and …
other cell types. Glutaminase activity is positively correlated with malignancy in tumours and …
Antioxidant potential by arabinoxylan rice bran, MGN-3/biobran, represents a mechanism for its oncostatic effect against murine solid Ehrlich carcinoma
E Noaman, NKB El-Din, MA Bibars… - Cancer letters, 2008 - Elsevier
We have recently examined the oncolytic effect of arabinoxylan rice bran, MGN-3/biobran,
against solid Ehrlich carcinoma (SEC)-bearing mice via immune-modulation and apoptosis …
against solid Ehrlich carcinoma (SEC)-bearing mice via immune-modulation and apoptosis …
Antioxidant defense in children with chronic viral hepatitis B and C
AM Chrobot, A Szaflarska-Szczepanik… - Medical Science …, 2000 - medscimonit.com
Introduction: The aim of the study was estimation of antioxidant defence state in children with
chronic viral hepatitis. Material and methods: We examined 100 children with chronic viral …
chronic viral hepatitis. Material and methods: We examined 100 children with chronic viral …
Ascorbate potentiates the cytotoxicity of menadione leading to an oxidative stress that kills cancer cells by a non-apoptotic caspase-3 independent form of cell death
J Verrax, J Cadrobbi, C Marques, H Taper, Y Habraken… - Apoptosis, 2004 - Springer
Hepatocarcinoma cells (TLT) were incubated in the presence of ascorbate and menadione,
either alone or in combination. Cell death was only observed when such compounds were …
either alone or in combination. Cell death was only observed when such compounds were …
Mitochondrial or cytosolic catalase reverses the MnSOD-dependent inhibition of proliferation by enhancing respiratory chain activity, net ATP production, and …
AM Rodrı́guez, PM Carrico, JE Mazurkiewicz… - Free Radical Biology …, 2000 - Elsevier
Manganese superoxide dismutase (MnSOD) overexpression has been shown to reverse the
malignant phenotype in a variety of tumor cell lines. The inhibition of proliferation and …
malignant phenotype in a variety of tumor cell lines. The inhibition of proliferation and …
Enhancement of quinone redox cycling by ascorbate induces a caspase-3 independent cell death in human leukaemia cells. An in vitro comparative study
J Verrax, M Delvaux, N Beghein, H Taper… - Free radical …, 2005 - Taylor & Francis
Since the higher redox potential of quinone molecules has been correlated with enhanced
cellular deleterious effects, we studied the ability of the association of ascorbate with several …
cellular deleterious effects, we studied the ability of the association of ascorbate with several …
Oxidative stress by ascorbate/menadione association kills K562 human chronic myelogenous leukaemia cells and inhibits its tumour growth in nude mice
J Verrax, J Stockis, A Tison, HS Taper… - Biochemical …, 2006 - Elsevier
The effect of oxidative stress induced by the ascorbate/menadione-redox association was
examined in K562 cells, a human erythromyeloid leukaemia cell line. Our results show that …
examined in K562 cells, a human erythromyeloid leukaemia cell line. Our results show that …
Mitochondrial superoxide dismutase: a promising target for new anticancer therapies
Compelling experimental and epidemiological evidence involves oxygen radicals in
carcinogenesis, acting reactive oxygen species both as endogenous genotoxins during cell …
carcinogenesis, acting reactive oxygen species both as endogenous genotoxins during cell …
Hsp90 cleavage by an oxidative stress leads to its client proteins degradation and cancer cell death
R Beck, J Verrax, T Gonze, M Zappone… - Biochemical …, 2009 - Elsevier
The heat shock protein 90 (Hsp90) plays a crucial role in the stability of several proteins that
are essential for malignant transformation. Hsp90 is therefore an interesting therapeutic …
are essential for malignant transformation. Hsp90 is therefore an interesting therapeutic …