Cell identity is largely determined by its transcriptional profile. In tumour, deregulation of
transcription factor expression and/or activity enables cancer cell to acquire a stem-like state …

DNA methylation is considered as a potential cancer biomarker. The evaluation of DNA
methylation level will contribute to the prognosis and diagnosis of cancer. Herein, we …

Epigenetic modifications and metabolism are two fundamental biological processes. During
tumorigenesis and cancer development both epigenetic and metabolic alterations occur and …

DNMT1 is an essential enzyme that maintains genomic DNA methylation, and its function is
regulated by mechanisms that are not yet fully understood. Here, we report the cryo-EM …

DNA methylation profiles are in dynamic equilibrium via the initiation of methylation,
maintenance of methylation and demethylation, which control gene expression and …

Centrosome and spindle pole-associated protein (CSPP1) is a centrosome and microtubule-
binding protein that plays a role in cell cycle-dependent cytoskeleton organization and cilia …

GABA is the most common inhibitory neurotransmitter in the vertebrate central nervous
system. Synthesized by glutamic acid decarboxylase, GABA could specifically bind with two …

Simple Summary Pediatric sarcomas, including Ewing sarcoma and osteosarcoma, were
first to be treated with an anticancer vaccine 100 years ago. This review moves on from a …

DNA methylation plays an important role in the silence of tissue-specific genes to prevent
them from being expressed in the wrong tissue. Aberrant DNA methylation (genome-wide …

Disruption of the epigenetic program of gene expression is a hallmark of cancer that initiates
and propagates tumorigenesis. Altered DNA methylation, histone modifications and ncRNAs …