[HTML][HTML] Inside the stemness engine: Mechanistic links between deregulated transcription factors and stemness in cancer
EH Ervin, R French, CH Chang, S Pauklin - Seminars in cancer biology, 2022 - Elsevier
Cell identity is largely determined by its transcriptional profile. In tumour, deregulation of
transcription factor expression and/or activity enables cancer cell to acquire a stem-like state …
transcription factor expression and/or activity enables cancer cell to acquire a stem-like state …
Endonuclease-assisted PAM-free recombinase polymerase amplification coupling with CRISPR/Cas12a (E-PfRPA/Cas) for sensitive detection of DNA methylation
S Zhou, J Dong, L Deng, G Wang, M Yang, Y Wang… - ACS …, 2022 - ACS Publications
DNA methylation is considered as a potential cancer biomarker. The evaluation of DNA
methylation level will contribute to the prognosis and diagnosis of cancer. Herein, we …
methylation level will contribute to the prognosis and diagnosis of cancer. Herein, we …
Interplay among metabolism, epigenetic modifications, and gene expression in cancer
M Huo, J Zhang, W Huang, Y Wang - Frontiers in Cell and …, 2021 - frontiersin.org
Epigenetic modifications and metabolism are two fundamental biological processes. During
tumorigenesis and cancer development both epigenetic and metabolic alterations occur and …
tumorigenesis and cancer development both epigenetic and metabolic alterations occur and …
Structural basis for activation of DNMT1
A Kikuchi, H Onoda, K Yamaguchi, S Kori… - Nature …, 2022 - nature.com
DNMT1 is an essential enzyme that maintains genomic DNA methylation, and its function is
regulated by mechanisms that are not yet fully understood. Here, we report the cryo-EM …
regulated by mechanisms that are not yet fully understood. Here, we report the cryo-EM …
[HTML][HTML] Blood-based DNA methylation signatures in cancer: A systematic review
Y Li, Z Fan, Y Meng, S Liu, H Zhan - … Acta (BBA)-Molecular Basis of Disease, 2023 - Elsevier
DNA methylation profiles are in dynamic equilibrium via the initiation of methylation,
maintenance of methylation and demethylation, which control gene expression and …
maintenance of methylation and demethylation, which control gene expression and …
[HTML][HTML] Identifies microtubule-binding protein CSPP1 as a novel cancer biomarker associated with ferroptosis and tumor microenvironment
W Wang, J Zhang, Y Wang, Y Xu, S Zhang - Computational and Structural …, 2022 - Elsevier
Centrosome and spindle pole-associated protein (CSPP1) is a centrosome and microtubule-
binding protein that plays a role in cell cycle-dependent cytoskeleton organization and cilia …
binding protein that plays a role in cell cycle-dependent cytoskeleton organization and cilia …
[HTML][HTML] GABAergic signaling as a potential therapeutic target in cancers
Y Yang, L Ren, W Li, Y Zhang, S Zhang, B Ge… - Biomedicine & …, 2023 - Elsevier
GABA is the most common inhibitory neurotransmitter in the vertebrate central nervous
system. Synthesized by glutamic acid decarboxylase, GABA could specifically bind with two …
system. Synthesized by glutamic acid decarboxylase, GABA could specifically bind with two …
Current state of immunotherapy and mechanisms of immune evasion in ewing sarcoma and osteosarcoma
V Evdokimova, H Gassmann, L Radvanyi… - Cancers, 2022 - mdpi.com
Simple Summary Pediatric sarcomas, including Ewing sarcoma and osteosarcoma, were
first to be treated with an anticancer vaccine 100 years ago. This review moves on from a …
first to be treated with an anticancer vaccine 100 years ago. This review moves on from a …
[HTML][HTML] DNA methylation: from cancer biology to clinical perspectives
C Chen, Z Wang, Y Ding, L Wang, S Wang… - Frontiers in Bioscience …, 2022 - imrpress.com
DNA methylation plays an important role in the silence of tissue-specific genes to prevent
them from being expressed in the wrong tissue. Aberrant DNA methylation (genome-wide …
them from being expressed in the wrong tissue. Aberrant DNA methylation (genome-wide …
Epigenetic reprogramming in cancer: From diagnosis to treatment
PMS Costa, SLA Sales, DP Pinheiro… - Frontiers in cell and …, 2023 - frontiersin.org
Disruption of the epigenetic program of gene expression is a hallmark of cancer that initiates
and propagates tumorigenesis. Altered DNA methylation, histone modifications and ncRNAs …
and propagates tumorigenesis. Altered DNA methylation, histone modifications and ncRNAs …