Next generation sequencing (NGS) has provided biologists with an unprecedented view into
biological processes and their regulation over the past 2 decades, fueling a wave of …

DNA methylation plays a critical role in the development of human tumors. However, routine
characterization of DNA methylation can be time-consuming and labor-intensive. We herein …

Background Downregulation of certain tumor-suppressor genes (TSGs) by aberrant
methylation of CpG islands in the promoter region contributes a great deal to the …

Introduction: The oncogenic transformation is driven by genetic and epigenetic alterations
influencing cancer cell fate. These alterations also result in metabolic reprogramming by …

In the last fifty years, large efforts have been deployed in basic research, clinical oncology,
and clinical trials, yielding an enormous amount of information regarding the molecular …

DNA methylation plays an important role in the silence of tissue-specific genes to prevent
them from being expressed in the wrong tissue. Aberrant DNA methylation (genome-wide …

Background Bivalent genes, of which promoters are marked by both H3K4me3
(trimethylation of histone H3 on lysine 4) and H3K27me3 (trimethylation of histone H3 on …

Introduction Lipid metabolic reprogramming is gaining attention as a hallmark of cancers.
Recent mounting evidence indicates that the malignant behavior of breast cancer (BC) is …

Malignant tumors remain one of the main sources of morbidity and mortality around the
world. A chemotherapeutic approach to cancer treatment poses a multitude of challenges …

DNA and RNA methylation dynamics have been linked to a variety of cellular processes
such as development, differentiation, and the maintenance of genome integrity. The correct …