Background The mechanisms whereby CYFIP2 acts in tumor development and drives
immune infiltration have been poorly explored. Thus, this study aimed to identifying the role …

The tumor microenvironment (TME) is crucial to neoplastic processes, fostering proliferation,
angiogenesis and metastasis. Epigenetic regulations, primarily including DNA and RNA …

DNA methylation is a fundamental mechanism of epigenetic control in cells and its
dysregulation is strongly implicated in cancer development. Cancers possess an extensively …

Breast cancer remains one of the leading causes of cancer-related deaths globally and the
most prominent among females, yet with limited effective therapeutic options. Most of the …

There is an urgent need for exploring new actionable targets other than androgen receptor
to improve outcome from lethal castration-resistant prostate cancer. Tumor metabolism has …

Multiple strategies are continuously being explored to expand the drug target repertoire in
solid tumors. We devised a novel computational workflow for transcriptome‐wide gene …

Epigenetic alterations, including aberrant DNA methylation, are now recognized as bone
fide hallmarks of cancer, which can contribute to cancer initiation, progression, therapy …

In recent years, high-throughput technologies have facilitated the widespread use of
metabolomics to identify biomarkers and targets for oral squamous cell carcinoma (OSCC) …

Background Downregulation of certain tumor-suppressor genes (TSGs) by aberrant
methylation of CpG islands in the promoter region contributes a great deal to the …

The present study investigates the molecular dynamics of Myc in normal precursors and in
different stages (I/II/III/IV) of cohorts of renal cancer using two distinct yet complementary …