Methylation of CpG-dinucleotides within proximal promoters is often associated with
transcriptional silencing. Methylation-dependent repression is well established for …

Introduction HTR2A gene has been the subject of numerous studies in psychiatric genetics
because LSD, which resembles serotonin causes psychosis and atypical antipsychotic …

Mechanisms regulating myofibroblastic differentiation of fibroblasts within fibroblastic foci in
idiopathic pulmonary fibrosis (IPF) remain unclear. Epigenetic processes, including DNA …

Cancer initiation and progression is controlled by both genetic and epigenetic events.
Epigenetics refers to the study of mechanisms that alter gene expression without …

SOCS1 and SHP1 negatively regulate the Janus kinase/signal transducer and activator of
transcription (Jak/STAT) signaling pathway. The role of promoter hypermethylation leading …

Objectives: T-cell DNA hypomethylation is thought to contribute to the development of
systemic erythematosus lupus (SLE). However, it is unknown whether impaired T-cell DNA …

Epigenetic alterations, such as histone modification, DNA methylation, and miRNA-mediated
processes, are critically associated with various mechanisms of proliferation and metastasis …

Cell surface expression of HLA class I/peptide complexes on tumor cells is a key step in the
generation of T‐cell‐based immune responses. Several genetic defects underlying the lack …

Atherosclerosis is a chronic disease characterised by lipid retention and inflammation in the
arterial intima. Innate immune mechanisms are central to atherogenesis, involving activation …

DNA methylation is a significant regulator of gene expression, and its role in carcinogenesis
recently has been a subject of remarkable interest. The aim of this review is to analyze the …