DNA methylation-based predictors of health: applications and statistical considerations
DNA methylation data have become a valuable source of information for biomarker
development, because, unlike static genetic risk estimates, DNA methylation varies …
development, because, unlike static genetic risk estimates, DNA methylation varies …
[HTML][HTML] Exposure to ambient air pollution in the first 1000 days of life and alterations in the DNA methylome and telomere length in children: a systematic review
Background Exposure to air pollution during the first 1000 days of life (from conception to the
2 nd year of life) might be of particular relevance for long-term child health. Changes in …
2 nd year of life) might be of particular relevance for long-term child health. Changes in …
Origins of human disease: the chrono-epigenetic perspective
ES Oh, A Petronis - Nature Reviews Genetics, 2021 - nature.com
Epigenetics has enriched human disease studies by adding new interpretations to disease
features that cannot be explained by genetic and environmental factors. However …
features that cannot be explained by genetic and environmental factors. However …
The complex biology of aryl hydrocarbon receptor activation in cancer and beyond
The aryl hydrocarbon receptor (AHR) signaling pathway is a complex regulatory network
that plays a critical role in various biological processes, including cellular metabolism …
that plays a critical role in various biological processes, including cellular metabolism …
[HTML][HTML] Maternal smoking during pregnancy induces persistent epigenetic changes into adolescence, independent of postnatal smoke exposure and is associated …
Background: Several studies have shown effects of current and maternal smoking during
pregnancy on DNA methylation of CpG sites in newborns and later in life. Here, we …
pregnancy on DNA methylation of CpG sites in newborns and later in life. Here, we …
EpiSmokEr: a robust classifier to determine smoking status from DNA methylation data
Aim: Smoking strongly influences DNA methylation, with current and never smokers
exhibiting different methylation profiles. Methods: To advance the practical applicability of …
exhibiting different methylation profiles. Methods: To advance the practical applicability of …
[HTML][HTML] DNA methylation links prenatal smoking exposure to later life health outcomes in offspring
Background Maternal smoking during pregnancy is associated with adverse offspring health
outcomes across their life course. We hypothesize that DNA methylation is a potential …
outcomes across their life course. We hypothesize that DNA methylation is a potential …
Epigenome-wide change and variation in DNA methylation in childhood: trajectories from birth to late adolescence
DNA methylation (DNAm) is known to play a pivotal role in childhood health and
development, but a comprehensive characterization of genome-wide DNAm trajectories …
development, but a comprehensive characterization of genome-wide DNAm trajectories …
A systematic review of smoking-related epigenetic alterations
The aim of this study is to provide a systematic review of the known epigenetic alterations
caused by cigarette smoke; establish an evidence-based perspective of their clinical value …
caused by cigarette smoke; establish an evidence-based perspective of their clinical value …
Developmental origins of type 2 diabetes: Focus on epigenetics
A Vaiserman, O Lushchak - Ageing Research Reviews, 2019 - Elsevier
Traditionally, genetics and lifestyle are considered as main determinants of aging-
associated pathological conditions. Accumulating evidence, however, suggests that risk of …
associated pathological conditions. Accumulating evidence, however, suggests that risk of …