Testis development
JA Mäkelä, JJ Koskenniemi, HE Virtanen… - Endocrine …, 2019 - academic.oup.com
Production of sperm and androgens is the main function of the testis. This depends on
normal development of both testicular somatic cells and germ cells. A genetic program …
normal development of both testicular somatic cells and germ cells. A genetic program …
[HTML][HTML] SOX17 is a critical specifier of human primordial germ cell fate
N Irie, L Weinberger, WWC Tang, T Kobayashi… - Cell, 2015 - cell.com
Specification of primordial germ cells (PGCs) marks the beginning of the totipotent state.
However, without a tractable experimental model, the mechanism of human PGC (hPGC) …
However, without a tractable experimental model, the mechanism of human PGC (hPGC) …
Specification and epigenetic programming of the human germ line
Primordial germ cells (PGCs), the precursors of sperm and eggs, are established in
perigastrulation-stage embryos in mammals. Signals from extra-embryonic tissues induce a …
perigastrulation-stage embryos in mammals. Signals from extra-embryonic tissues induce a …
The PRMT5 arginine methyltransferase: many roles in development, cancer and beyond
N Stopa, JE Krebs, D Shechter - Cellular and molecular life sciences, 2015 - Springer
Post-translational arginine methylation is responsible for regulation of many biological
processes. The protein arginine methyltransferase 5 (PRMT5, also known as Hsl7, Jbp1 …
processes. The protein arginine methyltransferase 5 (PRMT5, also known as Hsl7, Jbp1 …
Dynamic reprogramming of H3K9me3 at hominoid-specific retrotransposons during human preimplantation development
H Yu, M Chen, Y Hu, S Ou, X Yu, S Liang, N Li, M Yang… - Cell stem cell, 2022 - cell.com
Reprogramming of H3K9me3-dependent heterochromatin is required for early development.
How H3K9me3 is involved in early human development remains, however, largely unclear …
How H3K9me3 is involved in early human development remains, however, largely unclear …
[HTML][HTML] The regulatory function of piRNA/PIWI complex in cancer and other human diseases: The role of DNA methylation
DD Jia, H Jiang, YF Zhang, Y Zhang… - … journal of biological …, 2022 - ncbi.nlm.nih.gov
Piwi-interacting RNAs (piRNAs) are a class of short chain noncoding RNAs that are
constituted by 26-30 nucleotides (nt) and can couple with PIWI protein family. piRNAs were …
constituted by 26-30 nucleotides (nt) and can couple with PIWI protein family. piRNAs were …
The impact of transposable elements on mammalian development
JL Garcia-Perez, TJ Widmann, IR Adams - Development, 2016 - journals.biologists.com
Despite often being classified as selfish or junk DNA, transposable elements (TEs) are a
group of abundant genetic sequences that have a significant impact on mammalian …
group of abundant genetic sequences that have a significant impact on mammalian …
Fanconi anemia DNA crosslink repair factors protect against LINE-1 retrotransposition during mouse development
N Bona, GP Crossan - Nature Structural & Molecular Biology, 2023 - nature.com
Long interspersed nuclear element 1 (LINE-1) is the only autonomous retrotransposon in
humans and new integrations are a major source of genetic variation between individuals …
humans and new integrations are a major source of genetic variation between individuals …
[HTML][HTML] Transposable elements are regulated by context-specific patterns of chromatin marks in mouse embryonic stem cells
The majority of mammalian genomes are devoted to transposable elements (TEs). Whilst
TEs are increasingly recognized for their important biological functions, they are a potential …
TEs are increasingly recognized for their important biological functions, they are a potential …