Reactive metabolites of the anticonvulsant drugs and approaches to minimize the adverse drug reaction
Several generations of antiepileptic drugs (AEDs) are available in the market for the
treatment of seizures, but these are amalgamated with acute to chronic side effects. The …
treatment of seizures, but these are amalgamated with acute to chronic side effects. The …
[HTML][HTML] Challenges in the treatment of convulsive status epilepticus
G Zaccara, G Giannasi, R Oggioni, E Rosati… - Seizure, 2017 - Elsevier
Convulsive status epilepticus (CSE) is a medical emergency associated with high mortality
and morbidity. The most recent definition of CSE is a convulsive seizure lasting more than 5 …
and morbidity. The most recent definition of CSE is a convulsive seizure lasting more than 5 …
Maternal benzodiazepines and Z-drugs use during pregnancy and adverse birth and neurodevelopmental outcomes in offspring: a population-based cohort study
Introduction: The use of benzodiazepines and/or z-drugs in women of childbearing age has
increased. Objective: The aim of the study was to evaluate whether gestational …
increased. Objective: The aim of the study was to evaluate whether gestational …
Anticonvulsant effect of (±) citronellal possibly through the GABAergic and voltage-gated sodium channel receptor interaction pathways: In vivo and in silico studies
This study aimed to investigate the anticonvulsant effects of citronellal (CIT) and possible
underlying mechanisms through an isoniazid (INH)-induced seizure (convulsion) via in vivo …
underlying mechanisms through an isoniazid (INH)-induced seizure (convulsion) via in vivo …
Safety and efficacy of midazolam nasal spray in the outpatient treatment of patients with seizure clusters: an open‐label extension trial
JW Wheless, TC Meng, PJ Van Ess, K Detyniecki… - …, 2019 - Wiley Online Library
Objective To evaluate safety‐and seizure‐related outcomes with repeated intermittent use of
a novel formulation of midazolam administered as a single‐dose nasal spray (MDZ‐NS) in …
a novel formulation of midazolam administered as a single‐dose nasal spray (MDZ‐NS) in …
Biallelic variants in SLC38A3 encoding a glutamine transporter cause epileptic encephalopathy
The solute carrier (SLC) superfamily encompasses> 400 transmembrane transporters
involved in the exchange of amino acids, nutrients, ions, metals, neurotransmitters and …
involved in the exchange of amino acids, nutrients, ions, metals, neurotransmitters and …
[HTML][HTML] Diazepam effects on local cortical neural activity during sleep in mice
GABA-ergic neurotransmission plays a key role in sleep regulatory mechanisms and in brain
oscillations during sleep. Benzodiazepines such as diazepam are known to induce sedation …
oscillations during sleep. Benzodiazepines such as diazepam are known to induce sedation …
Sleep-disordered breathing in epilepsy: epidemiology, mechanisms, and treatment
Epilepsy is a group of neurological conditions in which there is a pathological and enduring
predisposition to generate recurrent seizures. Evidence over the last few decades suggests …
predisposition to generate recurrent seizures. Evidence over the last few decades suggests …
Effects of chronic diazepam exposure on the behaviors and oxidative stress homeostasis in the eyes and brains of female Japanese medaka
S Wang, J Dong, K Chen, Y Shi, X Qiu - Comparative Biochemistry and …, 2024 - Elsevier
Diazepam (DZP) residue has been frequently detected in wastewater, surface water, and
groundwater due to its extensive use over the decades. In this study, we exposed female …
groundwater due to its extensive use over the decades. In this study, we exposed female …
[HTML][HTML] Obstructive sleep apnea and epilepsy: understanding the pathophysiology of the comorbidity
Obstructive sleep apnea (OSA) is a sleep disorder of significant health concern with a high
prevalence in the general population. It has been found to exhibit a high incidence of …
prevalence in the general population. It has been found to exhibit a high incidence of …