Introduction The reclassification of membranoproliferative glomerulonephritis (MPGN) into
immune-complex MPGN (IC-MPGN) and C3 glomerulopathy (C3G) has provided insights …

C3 glomerulopathy (C3G) is an umbrella classification for severe renal diseases
characterized by predominant staining for complement component C3 in the glomeruli. The …

C3 glomerulopathy (C3G) is a severe kidney disease, which is caused by defective
regulation of the alternative complement pathway. Disease pathogenesis is heterogeneous …

Many 'hemolysis syndromes' overlap clinically with aHUS, and we review the literature on
the treatment of these conditions with complement inhibition. New reports on the treatment of …

Overactivation of the alternative pathway of the complement system is associated with the
renal diseases atypical hemolytic uremic syndrome (aHUS) and C3 glomerulopathy (C3G) …

Alternative pathway complement dysregulation with abnormal glomerular C3 deposits and
glomerular damage is a key mechanism of pathology in C3 glomerulopathy (C3G). No …

Introduction Myelodysplastic syndromes (MDS) are characterized by a high prevalence of
associated autoimmune manifestations. Kidney involvement has been rarely reported in …

Abstract Background C3 glomerulopathy (C3G) is characterized by heterogeneous clinical
presentation, outcome, and predominant C3 accumulation in glomeruli without significant …

Complement alternative pathway (AP) dysregulation drives C3 glomerulopathy (C3G), a rare
renal disorder characterized by glomerular C3 deposition and glomerular damage, for which …

The complement system plays a significant role within the pathological process of C3
glomerulopathy (C3GP) and atypical hemolytic uremic syndrome (aHUS). In daily practice …