Epigenetic modifications in DNA bases and histone proteins play important roles in the
regulation of gene expression and genome stability. Chemical modification of DNA base …

DNA methylation is an epigenetic mark that regulates multiple processes, such as gene
expression and genome stability. Mutants and pharmacological treatments have been …

As the evolutionary ancestor of Cas12 nuclease, the transposon (IS200/IS605)-encoded
TnpB proteins act as compact RNA-guided DNA endonucleases. To explore their …

Ten-eleven translocation (TET) family proteins (TETs), specifically, TET1, TET2 and TET3,
can modify DNA by oxidizing 5-methylcytosine (5mC) iteratively to yield 5 …

DNA-editing enzymes perform chemical reactions on DNA nucleobases. These reactions
can change the genetic identity of the modified base or modulate gene expression. Interest …

Chromatin adopts different configurations that are regulated by reversible covalent
modifications, referred to as epigenetic marks. Epigenetic inhibitors have been approved for …

Cardiovascular disease is the major cause of morbidity and mortality in breast cancer
survivors. Chemotherapy contributes to this risk. We aimed to define the mechanisms of long …

CD4+ regulatory T cells (Tregs) are key mediators of immunological tolerance and
promising effector cells for immuno-suppressive adoptive cellular therapy to fight …

Meiotic recombination is a major evolutionary process generating genetic diversity at each
generation in sexual organisms. However, this process is highly regulated, with the majority …

Osteoarthritis (OA) is one of the most common degenerative joint diseases worldwide,
causing pain, disability, and decreased quality of life. The balance between regeneration …