The factor H (FH) protein family is emerging as a complex network of proteins controlling the
fate of the complement alternative pathway (AP) and dictating susceptibility to a wide range …

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus was identified in
China in 2019 as the causative agent of COVID-19, and quickly spread throughout the …

Background The identification of complement defects as major drivers of primary atypical
hemolytic uremic syndrome (HUS) has transformed the landscape of thrombotic …

Allergic conditions are associated with canonical and noncanonical activation of the
complement system leading to the release of several bioactive mediators with inflammatory …

Introduction Comprehensive genetic analysis is essential to clinical care of patients with
atypical haemolytic uremic syndrome (aHUS) to reinforce diagnosis, and to guide treatment …

Activation of the alternative pathway (AP) of complement is involved in the pathogenesis of
antineutrophil cytoplasmic antibody (ANCA)–associated vasculitis (AAV), although the …

Background Complement activation in atypical hemolytic uremic syndrome (aHUS), C3
glomerulonephropathy (C3G) and immune complex-mediated membranoproliferative …

We have attempted to explore further the involvement of complement components in the
host COVID-19 (Coronavirus disease-19) immune responses by targeted genotyping of …

In late 2020, one of us (RAH) was approached by the late Professor Sir Peter Lachmann and
invited to join him in co-editing a collection of articles focused on the alternative pathway …

Simple Summary Therapeutic anti-CD20 monoclonal antibodies (mAbs) are divided into two
types based on their dominant effector mechanism. In contrast to type I specimens …