The multi-factorial nature of clinical multidrug resistance in cancer
Curative cancer therapy remains a major challenge particularly in cancers displaying
multidrug resistance (MDR). The MDR phenotype is characterized by cross-resistance to a …
multidrug resistance (MDR). The MDR phenotype is characterized by cross-resistance to a …
Advances in the structure, mechanism and targeting of chemoresistance-linked ABC transporters
Cancer cells frequently display intrinsic or acquired resistance to chemically diverse
anticancer drugs, limiting therapeutic success. Among the main mechanisms of this …
anticancer drugs, limiting therapeutic success. Among the main mechanisms of this …
[HTML][HTML] Recent advances in understanding the pathogenesis of rheumatoid arthritis: new treatment strategies
AL Mueller, Z Payandeh, N Mohammadkhani… - Cells, 2021 - mdpi.com
Rheumatoid arthritis (RA) is considered a chronic systemic, multi-factorial, inflammatory, and
progressive autoimmune disease affecting many people worldwide. While patients show …
progressive autoimmune disease affecting many people worldwide. While patients show …
Curcumin and colorectal cancer: An update and current perspective on this natural medicine
W Weng, A Goel - Seminars in cancer biology, 2022 - Elsevier
Colorectal cancer (CRC) is one of most common malignancies worldwide and its incidence
is still growing. In spite of recent advances in targeted therapies, their clinical efficacy has …
is still growing. In spite of recent advances in targeted therapies, their clinical efficacy has …
Promoter DNA hypermethylation and paradoxical gene activation
DNA methylation is a stable epigenetic modification that contributes to the spatiotemporal
regulation of gene expression. The manner in which DNA methylation contributes to …
regulation of gene expression. The manner in which DNA methylation contributes to …
[HTML][HTML] Dietary compounds as epigenetic modulating agents in cancer
Á Carlos-Reyes, JS López-González… - Frontiers in …, 2019 - frontiersin.org
Epigenetic mechanisms control gene expression during normal development and their
aberrant regulation may lead to human diseases including cancer. Natural phytochemicals …
aberrant regulation may lead to human diseases including cancer. Natural phytochemicals …
Extracellular vesicles as a novel source of biomarkers in liquid biopsies for monitoring cancer progression and drug resistance
MH Vasconcelos, HR Caires, A Ābols… - Drug Resistance …, 2019 - Elsevier
Cancer-derived extracellular vesicles (EVs) have been detected in the bloodstream and
other biofluids of cancer patients. They carry various tumor-derived molecules such as …
other biofluids of cancer patients. They carry various tumor-derived molecules such as …
[HTML][HTML] The role of chromatin remodeler SMARCA4/BRG1 in brain cancers: a potential therapeutic target
SM Navickas, KA Giles, KH Brettingham-Moore… - Oncogene, 2023 - nature.com
The chromatin remodeler SMARCA4/BRG1 is a key epigenetic regulator with diverse roles
in coordinating the molecular programs that underlie brain tumour development. BRG1 …
in coordinating the molecular programs that underlie brain tumour development. BRG1 …
The clinical relevance of gene expression based prognostic signatures in colorectal cancer
Colorectal cancer (CRC) is one of the most prevalent cancers, with more than one million
new cases every year. In the last few decades, several advancements in therapeutic and …
new cases every year. In the last few decades, several advancements in therapeutic and …
Dietary nutrients shape gut microbes and intestinal mucosa via epigenetic modifications
J Wu, Y Zhao, X Wang, L Kong… - Critical reviews in …, 2022 - Taylor & Francis
The imbalance of intestinal microecology firstly impairs intestinal mucosa barrier and
function, then further damages the functions and homeostasis of distal organs, leading to …
function, then further damages the functions and homeostasis of distal organs, leading to …