The zebrafish is a recent addition to animal models of human cancer, and studies using this
model are rapidly contributing major insights. Zebrafish develop cancer spontaneously, after …

Organisms can change their physiological/behavioural traits to adapt and survive in
changed environments. However, whether these acquired traits can be inherited across …

Early vertebrate embryos must achieve totipotency and prepare for zygotic genome
activation (ZGA). To understand this process, we determined the DNA methylation (DNAme) …

It is widely accepted that the epigenome can act as the link between environmental cues,
both external and internal, to the organism and phenotype by converting the environmental …

Environmental epigenetics is a rapidly growing field which studies the effects of
environmental factors such as nutrition, stress, and exposure to compounds on epigenetic …

DNA methylation is dynamic through the life of an organism. Previous studies have primarily
focused on DNA methylation changes during very early embryogenesis. In this study, global …

Background The role of epigenetic modifications such as DNA methylation during vertebrate
sexual development is far from being clear. Using the zebrafish model, we tested the effects …

Background Zygotic genome activation (ZGA) occurs at the mid-blastula transition (MBT) in
zebrafish and is a period of extensive chromatin remodeling. Genome-scale gametic …

The role of epigenetics in development has garnered attention in recent years due to their
ability to modulate the embryonic developmental gene expression in response to the …

Reduced representation bisulfite sequencing (RRBS) has been used to profile DNA
methylation patterns in mammalian genomes such as human, mouse and rat. The …