Chronic lymphocytic leukemia (CLL) is caused by the accumulation of malignant B cells due
to a defect in apoptosis and the presence of small population of proliferating cells principally …

B-cell non-Hodgkin lymphoma (B-NHL) evolution and treatment are complicated by a high
prevalence of relapses primarily due to the ability of malignant B cells to interact with tumor …

Interactions between chronic lymphocytic leukemia (CLL) B cells and the bone marrow (BM)
microenvironment play a major function in the physiopathology of CLL. Extracellular vesicles …

The CXCL12–CXCR4 axis plays a key role in the retention of stem cells and progenitors in
dedicated bone marrow niches. It is well-known that CXCR4 responsiveness in B …

Purpose: Unmutated (UM) immunoglobulin heavy chain variable region (IgHV) status or
IgHV3-21 gene usage is associated with poor prognosis in chronic lymphocytic leukemia …

B-cell chronic lymphocytic leukemia (B-CLL) is one of the most common hematologic
malignancies in Western countries. Accumulation of leukemic lymphocytes in peripheral …

2 Shultz LD, Lyons BL, Burzenski LM, Gott B, Chen X, Chaleff S et al. Human lymphoid and
myeloid cell development in NOD/LtSz-scid IL2R gamma null mice engrafted with mobilized …

Background Interactions with the microenvironment, such as bone marrow mesenchymal
stromal cells and nurse-like cells, protect chronic lymphocytic leukemia cells from …

There is growing evidence that lymphocyte trafficking contributes to the clinical course of
chronic lymphocytic leukemia (CLL), but to date, only static in vitro cultures have been used …

Chronic lymphocytic leukemia (CLL) is a type of highly heterogeneous mature B-cell
malignancy with various disease courses. Although a multitude of prognostic markers in CLL …