Experimental modification of the membrane structure of rat liver microsomes affected the
behavior of the 11-oxidase and 11-reductase components of 11 β-hydroxysteroid …

Objectives: Indirect evidence suggests that adrenal steroid production in the human fetus
may have a circadian rhythm. To assess whether there is a 24-hour rhythm of fetal cortisol in …

Steroid metabolism was investigated in cultured human B-lymphoblastoid cells (B-LCL), and
peripheral blood T and B cells. Gene expression was examined by reverse-transcription …

The enzyme 11 β-hydroxysteroid dehydrogenase (11-HSD) appears to be involved in
mediating aldosterone specificity of otherwise nonselective type I receptors in …

Rupture of fetal membranes (ROM) can initiate parturition at both term and preterm birth.
Apoptosis of the amnion epithelium plays a key role in structural remodeling of the …

Glucocorticoids (GCs) are essential to normal lung development. They participate in the
regulation of important developmental events including morphological changes, and lung …

To date, two isoforms of 11β-hydroxysteroid dehydrogenase (11βSD) have been
characterized: a low affinity, NADP+-dependent isoform (11βSD1) and a high affinity, NAD+ …

The mechanisms underlying human parturition are still not understood, yet we need this
knowledge to combat preterm birth. Fetal membranes express abundant 11β-hydroxysteroid …

The fetal membranes are equipped with high capacity of cortisol regeneration through the
reductase activity of 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1). The expression of …

Rupture of fetal membranes (ROM) can initiate parturition at both term and preterm.
Collagen III in the compact layer of the amnion contributes to the tensile strength of fetal …