Objective Little is known about the effect of social support on the reactivity of the
hypothalamic–pituitary–adrenal (HPA) axis during pregnancy. Moreover, when investigating …

11β-Hydroxysteroid dehydrogenase type 2 (11βHSD2) catalyzes the conversion of cortisol
to biologically inactive cortisone and is thought to confer specificity on mineralocorticoid …

In these studies our goal was to solubilize the microsomal enzyme, 11β-hydroxysteroid
dehydrogenase (11-HSD) as the first step in its purification. Enzyme was extracted from rat …

The syncytiotrophoblasts of the human placenta express high levels of 11β-hydroxysteroid
dehydrogenase type 2 (11β-HSD2), the enzyme responsible for the inactivation of …

An experiment was conducted in pigs to determine the source of fetal cortisol at 50 (n= 5) or
100 days (n= 4) of gestation (term= 114 days). Equilibrium concentrations of tritiated cortisol …

Cortisol is converted to the inactive glucocorticoid, cortisone, in several tissues by 11β-
hydroxysteroid dehydrogenase (11βHSD). We have recently measured 11βHSD activity in …

Introduction Infants born below 2500 g are classified as low birth weight. Excess in utero
exposure to cortisol has been linked to restricted fetal growth. Placental production of 11β …

11β-Hydroxysteroid dehydrogenase type II (11βHSD2) confers specificity on the
mineralocorticoid receptor (MR) by converting biologically active glucocorticoids to inactive …

Preterm premature rupture of fetal membranes precedes 30–40% of preterm births.
Activation of matrix metalloproteases (MMPs) is the one of the major causes of extracellular …

Purpose In previous studies, associations between breast-milk cortisol levels obtained on
one occasion and infant neurodevelopment were demonstrated. However, more recent …