Heart disease and stroke statistics—2019 update: a report from the American Heart Association

EJ Benjamin, P Muntner, A Alonso, MS Bittencourt… - Circulation, 2019 - Am Heart Assoc
Summary Each year, the American Heart Association (AHA), in conjunction with the National
Institutes of Health and other government agencies, brings together in a single document the …

Angiotensin II signal transduction: an update on mechanisms of physiology and pathophysiology

SJ Forrester, GW Booz, CD Sigmund… - Physiological …, 2018 - journals.physiology.org
The renin-angiotensin-aldosterone system plays crucial roles in cardiovascular physiology
and pathophysiology. However, many of the signaling mechanisms have been unclear. The …

Heart disease and stroke statistics—2020 update: a report from the American Heart Association

SS Virani, A Alonso, EJ Benjamin, MS Bittencourt… - Circulation, 2020 - Am Heart Assoc
Background: The American Heart Association, in conjunction with the National Institutes of
Health, annually reports on the most up-to-date statistics related to heart disease, stroke …

[HTML][HTML] Heart disease and stroke statistics-2021 update: a report from the American Heart Association.

SS Virani, A Alonso, HJ Aparicio, EJ Benjamin… - 2021 - dukespace.lib.duke.edu
Background The American Heart Association, in conjunction with the National Institutes of
Health, annually reports the most up-to-date statistics related to heart disease, stroke, and …

Inhibition of macrophage histone demethylase JMJD3 protects against abdominal aortic aneurysms

FM Davis, LC Tsoi, WJ Melvin, A DenDekker… - Journal of Experimental …, 2021 - rupress.org
Abdominal aortic aneurysms (AAAs) are a life-threatening disease for which there is a lack
of effective therapy preventing aortic rupture. During AAA formation, pathological vascular …

[HTML][HTML] Genetic and epigenetic mechanisms underlying vascular smooth muscle cell phenotypic modulation in abdominal aortic aneurysm

R Gurung, AM Choong, CC Woo, R Foo… - International journal of …, 2020 - mdpi.com
Abdominal aortic aneurysm (AAA) refers to the localized dilatation of the infra-renal aorta, in
which the diameter exceeds 3.0 cm. Loss of vascular smooth muscle cells, degradation of …

[HTML][HTML] Endothelial pannexin-1 channels modulate macrophage and smooth muscle cell activation in abdominal aortic aneurysm formation

AC Filiberto, MD Spinosa, CT Elder, G Su… - Nature …, 2022 - nature.com
Abstract Pannexin-1 (Panx1) channels have been shown to regulate leukocyte trafficking
and tissue inflammation but the mechanism of Panx1 in chronic vascular diseases like …

Renin-angiotensin system and cardiovascular functions

CH Wu, S Mohammadmoradi, JZ Chen… - … , and vascular biology, 2018 - Am Heart Assoc
Wu et al The RAS and Cardiovascular Functions e109 homocysteine decreased
antihypertensive effect of enalapril, an ACE inhibitor, in chronic hypertensive patients. 61 …

[HTML][HTML] TGF-β signaling-related genes and thoracic aortic aneurysms and dissections

N Takeda, H Hara, T Fujiwara, T Kanaya… - International journal of …, 2018 - mdpi.com
Transforming growth factor-β (TGF)-β signaling plays a crucial role in the development and
maintenance of various organs, including the vasculature. Accordingly, the mutations in TGF …

[HTML][HTML] Role of extracellular matrix and inflammation in abdominal aortic aneurysm

KL Stepien, K Bajdak-Rusinek, A Fus-Kujawa… - International journal of …, 2022 - mdpi.com
Abdominal aortic aneurysm (AAA) is one of the most dangerous cardiovascular diseases,
occurring mainly in men over the age of 55 years. As it is asymptomatic, patients are …