[HTML][HTML] The role of m6A modification in the biological functions and diseases
X Jiang, B Liu, Z Nie, L Duan, Q Xiong, Z Jin… - Signal transduction and …, 2021 - nature.com
Abstract N6-methyladenosine (m6A) is the most prevalent, abundant and conserved internal
cotranscriptional modification in eukaryotic RNAs, especially within higher eukaryotic cells …
cotranscriptional modification in eukaryotic RNAs, especially within higher eukaryotic cells …
Testis development
JA Mäkelä, JJ Koskenniemi, HE Virtanen… - Endocrine …, 2019 - academic.oup.com
Production of sperm and androgens is the main function of the testis. This depends on
normal development of both testicular somatic cells and germ cells. A genetic program …
normal development of both testicular somatic cells and germ cells. A genetic program …
[HTML][HTML] In toto imaging and reconstruction of post-implantation mouse development at the single-cell level
The mouse embryo has long been central to the study of mammalian development;
however, elucidating the cell behaviors governing gastrulation and the formation of tissues …
however, elucidating the cell behaviors governing gastrulation and the formation of tissues …
Stress-induced perinatal and transgenerational epigenetic programming of brain development and mental health
O Babenko, I Kovalchuk, GAS Metz - Neuroscience & Biobehavioral …, 2015 - Elsevier
Research efforts during the past decades have provided intriguing evidence suggesting that
stressful experiences during pregnancy exert long-term consequences on the future mental …
stressful experiences during pregnancy exert long-term consequences on the future mental …
[HTML][HTML] Reconstitution of the mouse germ cell specification pathway in culture by pluripotent stem cells
K Hayashi, H Ohta, K Kurimoto, S Aramaki, M Saitou - Cell, 2011 - cell.com
The generation of properly functioning gametes in vitro requires reconstitution of the
multistepped pathway of germ cell development. We demonstrate here the generation of …
multistepped pathway of germ cell development. We demonstrate here the generation of …
[HTML][HTML] The germ cell fate of cynomolgus monkeys is specified in the nascent amnion
K Sasaki, T Nakamura, I Okamoto, Y Yabuta… - Developmental cell, 2016 - cell.com
The germ cell lineage ensures reproduction and heredity. The mechanism for germ cell
specification in primates, including humans, has remained unknown. In primates, upon …
specification in primates, including humans, has remained unknown. In primates, upon …
Germline selection shapes human mitochondrial DNA diversity
INTRODUCTION Only 2.4% of the 16.5-kb mitochondrial DNA (mtDNA) genome shows
homoplasmic variation at> 1% frequency in humans. Migration patterns have contributed to …
homoplasmic variation at> 1% frequency in humans. Migration patterns have contributed to …
[HTML][HTML] Molecular control of oogenesis
F Sánchez, J Smitz - Biochimica et Biophysica Acta (BBA)-Molecular Basis …, 2012 - Elsevier
Oogenesis is a complex process regulated by a vast number of intra-and extra-ovarian
factors. Oogonia, which originate from primordial germ cells, proliferate by mitosis and form …
factors. Oogonia, which originate from primordial germ cells, proliferate by mitosis and form …
Reprogramming DNA methylation in the mammalian life cycle: building and breaking epigenetic barriers
In mammalian development, epigenetic modifications, including DNA methylation patterns,
play a crucial role in defining cell fate but also represent epigenetic barriers that restrict …
play a crucial role in defining cell fate but also represent epigenetic barriers that restrict …
[HTML][HTML] Newly identified regulators of ovarian folliculogenesis and ovulation
E Gershon, N Dekel - International journal of molecular sciences, 2020 - mdpi.com
Each follicle represents the basic functional unit of the ovary. From its very initial stage of
development, the follicle consists of an oocyte surrounded by somatic cells. The oocyte …
development, the follicle consists of an oocyte surrounded by somatic cells. The oocyte …