Barriers to progress in pregnancy research: How can we break through?

SJ Stock, CE Aiken - Science, 2023 - science.org
Healthy pregnancies are fundamental to healthy populations, but very few therapies to
improve pregnancy outcomes are available. Fundamental concepts—for example …

Role of Platelet Activating Factor as a Mediator of Inflammatory Diseases and Preterm Delivery

HH Wahid, FN Anahar, NH Isahak, JM Zoharodzi… - The American journal of …, 2024 - Elsevier
Nearly 70% of preterm deliveries occur spontaneously, and the clinical pathways involved
include preterm labor and preterm premature rupture of membranes. Prediction of preterm …

Association between interleukin-6 and preterm birth: a meta-analysis

Y Chang, W Li, Y Shen, S Li, X Chen - Annals of Medicine, 2023 - Taylor & Francis
Abstract Background Interleukin (IL)-6 is a pro-inflammatory cytokine that plays an important
role in preterm birth (PTB), Several meta-analyses investigated the association between IL-6 …

Endocrine-disrupting compounds and their impact on human placental function: evidence from placenta organ-on-chip studies

MS Vidal, LS Richardson, AK Kammala, S Kim… - Lab on a Chip, 2024 - pubs.rsc.org
The effects of endocrine-disrupting compounds (EDCs) on the placenta, a critical gestational
organ for xenobiotic protection, are well reported; however, models to determine the role of …

[HTML][HTML] Intrauterine growth restriction, prematurity, and low birth weight: risk phenotypes of neonatal death, Rio de Janeiro State, Brazil

PL Kale, SC Fonseca - Cadernos de Saúde Pública, 2023 - SciELO Brasil
Intrauterine growth restriction and prematurity determine low birth weight. The combination
of the three conditions results in different neonatal phenotypes that interfere with child …

New approach methods on the bench side to accelerate clinical trials during pregnancy

R Menon, L Richardson… - Expert Opinion on Drug …, 2024 - Taylor & Francis
Introduction Pregnant women are therapeutic orphans as they are excluded from clinical
drug development and therapeutic trials. We identify limitations in conducting clinical trials …

[HTML][HTML] A genome-wide and candidate gene association study of preterm birth in Korean pregnant women

YM Hur, JY Yoo, YA You, S Park, SM Kim, G Lee… - Plos one, 2023 - journals.plos.org
Preterm birth (PTB) refers to delivery before 37 weeks of gestation. Premature neonates
exhibit higher neonatal morbidity and mortality rates than term neonates; therefore, it is …

Phenanthroline relaxes uterine contractions induced by diverse contractile agents by decreasing cytosolic calcium concentration

M Qu, P Lu, LM Lifshitz, TAM Simas, E Delpapa… - European Journal of …, 2024 - Elsevier
Uterine contractions during labor and preterm labor are influenced by a complex interplay of
factors, including hormones and inflammatory mediators. This complexity may contribute to …

[HTML][HTML] Maternal & perinatal outcome of fever in pregnancy in the context of dengue-A retrospective observational study

H Sagili, RS Krishna, R Dhodapkar… - Indian Journal of …, 2022 - journals.lww.com
Methods: A retrospective observational study was conducted on pregnant women admitted
with fever, in a tertiary referral centre in South India, during January 2015 to December …

[HTML][HTML] Restrição do crescimento intrauterino, prematuridade e baixo peso ao nascer: fenótipos de risco de morte neonatal, Estado do Rio de Janeiro, Brasil

PL Kale, SC Fonseca - Cadernos de Saúde Pública, 2023 - SciELO Brasil
A restrição do crescimento intrauterino ea prematuridade determinam o baixo peso ao
nascer, ea combinação das três condições resulta em diferentes fenótipos neonatais que …