Epilepsy is a common and serious neurologic disease with a strong genetic component.
Genetic studies have identified an increasing collection of disease-causing genes. The …

Hyperpolarization-activated cyclic nucleotide–gated (HCN) channels are expressed as four
different isoforms (HCN1-4) in the heart and in the central and peripheral nervous systems …

Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels underlie the control of
rhythmic activity in cardiac and neuronal pacemaker cells. In HCN, the polarity of voltage …

INTRODUCTION SHANK3 is a scaffolding protein that is enriched in postsynaptic densities
of excitatory synapses but ubiquitously expressed in most cells. SHANK3 gene mutations …

Ion channels are crucial in the generation and modulation of excitability in the nervous
system and have been implicated in human epilepsy. Forty-one epilepsy-associated ion …

Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels control neuronal
excitability and their dysfunction has been linked to epileptogenesis but few individuals with …

Hyperpolarization-activated, cyclic nucleotide–gated (HCN) channels are important
members of the voltage-gated pore loop channels family. They show unique features: they …

Highlights•HS-AFM detects conformational changes of unlabeled membrane proteins.•In situ
responses to pH, ligands, temperature and light can be visualized.•Developments in …

A-type voltage-gated potassium (Kv) channels are major regulators of neuronal excitability
that have been mainly characterized in the central nervous system. By contrast, there is a …

Absence epilepsy is an idiopathic generalized non-convulsive type of epilepsy associated
with aberrant activity in the thalamocortical network. The common neuronal network …