The therapeutic algorithm of renal cell carcinoma has been revolutionized by the approval of
immunotherapy agents by regulatory agencies. However, objective and durable responses …

Renal cell carcinoma (RCC) has the highest mortality rate of all genitourinary cancers, and
its prevalence has grown over time. While RCC can be surgically treated and recurrence is …

Clear cell renal cell carcinoma (ccRCC) is the most prevalent subtype of renal cell
carcinoma, which is characterized by metabolic reprogramming. Cuproptosis, a novel form …

Ferroptosis, a novel form of regulated cell death characterized by disrupted iron metabolism
and the accumulation of lipid peroxides, has exhibited enormous potential in the therapy of …

Celastrol is a pentacyclic triterpenoid extracted from the traditional Chinese medicine
Tripterygium wilfordii Hook F., which has multiple pharmacological activities. In particular …

Background Distant metastasis is the major cause of clear cell renal cell carcinoma (ccRCC)-
associated mortality. However, molecular mechanisms involved in ccRCC metastasis …

Background: Renal cell carcinoma (RCC) is a common malignancy with approximately 30%
of cases diagnosed at the advanced or metastatic stage. While single-agent vascular …

The incidence of metabolism-related diseases like obesity and type 2 diabetes mellitus has
reached pandemic levels worldwide and increased gradually. Most of them are listed on the …

Ferroptosis, a nonapoptotic form of programmed cell death characterized by significant iron-
dependent peroxidation of phospholipids, is regulated by cellular metabolism, redox …

Clear cell renal cell carcinoma (ccRCC) is a heterogeneous tumor with different genetic and
molecular alterations. Schemes for ccRCC classification system based on multiomics are …