Stem cells and interspecies chimaeras

J Wu, HT Greely, R Jaenisch, H Nakauchi, J Rossant… - Nature, 2016 - nature.com
Chimaeras are both monsters of the ancient imagination and a long-established research
tool. Recent advances, particularly those dealing with the identification and generation of …

[HTML][HTML] Transplantation of human brain organoids: revisiting the science and ethics of brain chimeras

HI Chen, JA Wolf, R Blue, MM Song, JD Moreno… - Cell stem cell, 2019 - cell.com
Recent demonstrations of human brain organoid transplantation in rodents have
accentuated ethical concerns associated with these entities, especially as they relate to …

[图书][B] What it means to be human: Historical reflections from the 1800s to the Present

J Bourke - 2013 - books.google.com
In 1872, a woman known only as" An Earnest Englishwoman" published a letter titled" Are
Women Animals?" in which she protested against the fact that women were not treated as …

Mapping the ethical issues of brain organoid research and application

T Sawai, Y Hayashi, T Niikawa, J Shepherd… - AJOB …, 2022 - Taylor & Francis
In 2008, researchers created human three-dimensional neural tissue–known as the
pioneering work of “brain organoids.” In recent years, some researchers have transplanted …

Human brain surrogates research: the onrushing ethical dilemma

HT Greely - The American Journal of Bioethics, 2021 - Taylor & Francis
Human brain research is moving into a dilemma. The best way to understand how the
human brain works is to study living human brains in living human beings, but ethical and …

[图书][B] The ethics of species: An introduction

RL Sandler - 2012 - books.google.com
We are causing species to go extinct at extraordinary rates, altering existing species in
unprecedented ways, and creating entirely new species. More than ever before, we require …

At the edge of humanity: human stem cells, chimeras, and moral status

R Streiffer - Kennedy Institute of Ethics Journal, 2005 - muse.jhu.edu
Experiments involving the transplantation of human stem cells and their derivatives into
early fetal or embryonic nonhuman animals raise novel ethical issues due to their possible …

[HTML][HTML] The moral status of cerebral organoids

S Hostiuc, MC Rusu, I Negoi, P Perlea, B Dorobanţu… - Regenerative …, 2019 - Elsevier
Organoids are 3D biological structures constructed from stem cells in vitro. They partially
mimic the function of real organs. Although the number of articles detailing this technology …

[HTML][HTML] Ethical arguments concerning human-animal chimera research: a systematic review

K Kwisda, L White, D Hübner - BMC Medical Ethics, 2020 - Springer
Background The burgeoning field of biomedical research involving the mixture of human
and animal materials has attracted significant ethical controversy. Due to the many …

Thinking about the human neuron mouse

HT Greely, MK Cho, LF Hogle… - The American Journal of …, 2007 - Taylor & Francis
Dr. Irving Weissman, a professor in the departments of pathology and developmental
biology at Stanford University (Stanford, CA), approached one of the authors of this article in …