Copper homeostasis is strictly regulated by protein transporters and chaperones, to allow its
correct distribution and avoid uncontrolled redox reactions. Several studies address copper …

The sustained growth, invasion, and metastasis of cancer cells depend upon bidirectional
cell–cell communication within complex tissue environments. Such communication …

Reactive oxygen species (ROS) are important signaling molecules in cancer. The level of
ROS will determine physiological effects. While high levels of ROS can cause damage to …

Exosomes are extracellular nanovesicles primarily involved in the pathogenesis of many
diseases including cancer. This study was set out from recent evidence that extracellular …

Exosomes, biological extracellular vesicles, have recently begun to find use in targeted drug
delivery in solid tumor research. Ranging from 30–120 nm in size, exosomes are secreted …

Local acidification of stroma is proposed to favour pre-metastatic niche formation but the
mechanism of initiation is unclear. We investigated whether Human Melanoma-derived …

Cancer-associated fibroblasts (CAFs) are important cells of the tumor microenvironment that
can communicate with tumor cells through various mechanisms. Recently, increasing …

Gastric cancer (GC) is one of the leading causes of cancer-related death in both men and
women due to delayed diagnosis and high metastatic frequency. Extracellular vesicles (EVs) …

Even though pancreatic ductal adenocarcinoma (PDAC) is associated with fibrotic stroma,
the molecular pathways regulating the formation of cancer associated fibroblasts (CAFs) are …

Cell-in-cell structures are reported in numerous cancers, and their presence is an indicator
for poor prognosis. Mechanistic studies have identified how cancer cells manage to ingest …