Alterations in DNA methylation: a fundamental aspect of neoplasia
Neoplastic cells simultaneously harbor widespread genomic hypomethylation, more
regional areas of hypermethylation, and increased DNA-methyltransferase (DNA-MTase) …
regional areas of hypermethylation, and increased DNA-methyltransferase (DNA-MTase) …
Changes in DNA methylation in neoplasia: pathophysiology and therapeutic implications
V Santini, HM Kantarjian, JP Issa - Annals of internal medicine, 2001 - acpjournals.org
Methylation of DNA is a biochemical modification that can influence gene expression and is
involved in inactivating one of the two X chromosomes in women. Evidence that has …
involved in inactivating one of the two X chromosomes in women. Evidence that has …
Covalent modification of DNA regulates memory formation
CA Miller, JD Sweatt - Neuron, 2007 - cell.com
DNA methylation is a covalent chemical modification of DNA catalyzed by DNA
methyltransferases (DNMTs). DNA methylation is associated with transcriptional silencing …
methyltransferases (DNMTs). DNA methylation is associated with transcriptional silencing …
Evidence that DNA (cytosine-5) methyltransferase regulates synaptic plasticity in the hippocampus
DNA (cytosine-5) methylation represents one of the most widely used mechanisms of
enduring cellular memory. Stable patterns of DNA methylation are established during …
enduring cellular memory. Stable patterns of DNA methylation are established during …
DNA methylation and cancer
PW Laird, R Jaenisch - Human molecular genetics, 1994 - academic.oup.com
Changes in the pattern of DNA methylation have been a consistent finding in cancer cells.
The mostly descriptive nature of these studies and the fact that both hypo-and …
The mostly descriptive nature of these studies and the fact that both hypo-and …
Expression of DNA methyltransferase gene in mature and immature neurons as well as proliferating cells in mice
K Goto, M Numata, JI Komura, T Ono, TH Bestor… - Differentiation, 1994 - Elsevier
A major role of DNA-methyltransferase (MTase) is thought to be maintaining the DNA methyl-
ation profile through DNA replication. However, previous surveys of mRNA distribution in …
ation profile through DNA replication. However, previous surveys of mRNA distribution in …
Isolation and characterization of the cDNA encoding human DNA methyltransferase
RWC Yen, PM Vertino, BD Nelkin, JJ Yu… - Nucleic acids …, 1992 - academic.oup.com
We have cloned a series of overlapping cDNA clones encoding a 5194 bp transcript for
human DNA methyltransferase (DNA MTase). This sequence potentially codes for a protein …
human DNA methyltransferase (DNA MTase). This sequence potentially codes for a protein …
Inhibition of DNA methylation and histone deacetylation prevents murine lung cancer
SA Belinsky, DM Klinge, CA Stidley, JP Issa… - Cancer research, 2003 - AACR
Disruption of one allele for the cytosine-DNA methyltransferase 1 (DNMT1) gene in mice
with a germ-line mutation in a tumor suppressor gene was shown previously to reduce tumor …
with a germ-line mutation in a tumor suppressor gene was shown previously to reduce tumor …
Increased cytosine DNA-methyltransferase activity during colon cancer progression
JPJ Issa, PM Vertino, J Wu, S Sazawal… - JNCI: Journal of the …, 1993 - academic.oup.com
Background: Molecular changes during progressive stages of colon cancer and other
human tumors commonly involve altered regulation of DNA methylation. These changes …
human tumors commonly involve altered regulation of DNA methylation. These changes …
High expression of the DNA methyltransferase gene characterizes human neoplastic cells and progression stages of colon cancer.
WS El-Deiry, BD Nelkin, P Celano… - Proceedings of the …, 1991 - National Acad Sciences
DNA methylation abnormalities occur consistently in human neoplasia including widespread
hypomethylation and more recently recognized local increases in DNA methylation that hold …
hypomethylation and more recently recognized local increases in DNA methylation that hold …