Overview of tumor heterogeneity in high-grade serous ovarian cancers
E Azzalini, G Stanta, V Canzonieri, S Bonin - International Journal of …, 2023 - mdpi.com
Ovarian cancers encompass a group of neoplasms originating from germinal tissues and
exhibiting distinct clinical, pathological, and molecular features. Among these, epithelial …
exhibiting distinct clinical, pathological, and molecular features. Among these, epithelial …
New insights into ferroptosis initiating therapies (FIT) by targeting the rewired lipid metabolism in ovarian cancer peritoneal metastases
Ovarian cancer is one of the most lethal gynecological cancers worldwide. The poor
prognosis of this malignancy is substantially attributed to the inadequate symptomatic …
prognosis of this malignancy is substantially attributed to the inadequate symptomatic …
HSF-1/miR-145-5p transcriptional axis enhances hyperthermic intraperitoneal chemotherapy efficacy on peritoneal ovarian carcinosis
S Di Agostino, V Canu, S Donzelli, C Pulito… - Cell Death & …, 2023 - nature.com
Hyperthermic intraperitoneal administration of chemotherapy (HIPEC) increases local drug
concentrations and reduces systemic side effects associated with prolonged adjuvant …
concentrations and reduces systemic side effects associated with prolonged adjuvant …
Diagnostics of ovarian cancer via metabolite analysis and machine learning
JZ Yao, IF Tsigelny, S Kesari… - Integrative …, 2023 - academic.oup.com
Ovarian cancer (OC) is the second most common cancer of the female reproductive system.
Due to the asymptomatic nature of early stages of OC and an increasingly poor prognosis in …
Due to the asymptomatic nature of early stages of OC and an increasingly poor prognosis in …
DNA methylation and transcriptomic features are preserved throughout disease recurrence and chemoresistance in high grade serous ovarian cancers
Background Little is known about the role of global DNA methylation in recurrence and
chemoresistance of high grade serous ovarian cancer (HGSOC). Methods We performed …
chemoresistance of high grade serous ovarian cancer (HGSOC). Methods We performed …
Epigenetic silencing of miR-33b promotes peritoneal metastases of ovarian cancer by modulating the TAK1/FASN/CPT1A/NF-κB axis
Simple Summary Omental metastasis and peritoneal dissemination are frequently observed
in ovarian cancer peritoneal metastases and are associated with high mortality and poor …
in ovarian cancer peritoneal metastases and are associated with high mortality and poor …
Creation and validation of models to predict response to primary treatment in serous ovarian cancer
J Gonzalez Bosquet, EJ Devor, AM Newtson… - Scientific reports, 2021 - nature.com
Nearly a third of patients with high-grade serous ovarian cancer (HGSC) do not respond to
initial therapy and have an overall poor prognosis. However, there are no validated tools …
initial therapy and have an overall poor prognosis. However, there are no validated tools …
Stage-differentiated ensemble modeling of DNA methylation landscapes uncovers salient biomarkers and prognostic signatures in colorectal cancer progression
S Muthamilselvan, A Raghavendran, A Palaniappan - PloS one, 2022 - journals.plos.org
Background Aberrant DNA methylation acts epigenetically to skew the gene transcription
rate up or down, contributing to cancer etiology. A gap in our understanding concerns the …
rate up or down, contributing to cancer etiology. A gap in our understanding concerns the …
High-grade serous ovarian carcinoma, the “Achiles' hill” for clinicians and molecular biologists: a molecular insight
R Bhattacharya, A Ghosh, S Mukhopadhyay - Molecular Biology Reports, 2023 - Springer
High-grade serous ovarian carcinoma (HGSOC), the deadliest ovarian cancer, alone
accounts for 90% of all its subtypes. Characterized by hallmark mutation of TP53, HGSOC …
accounts for 90% of all its subtypes. Characterized by hallmark mutation of TP53, HGSOC …
Promoter hypermethylation of neural-related genes is compatible with stemness in solid cancers
M Idris, L Coussement, MM Alves, T De Meyer… - Epigenetics & …, 2023 - Springer
Background DNA hypermethylation is an epigenetic feature that modulates gene
expression, and its deregulation is observed in cancer. Previously, we identified a neural …
expression, and its deregulation is observed in cancer. Previously, we identified a neural …