Cells differentiate and progress through development guided by a dynamic chromatin
landscape that mediates gene expression programmes. During development, mammalian …

Cancer immunotherapy is a promising innovative treatment for many forms of cancer,
particularly melanoma. Although immunotherapy has been shown to be efficacious, patient …

Pluripotency of embryonic stem cells (ESCs) and induced pluripotent stem cells is regulated
by a well characterized gene transcription circuitry. The circuitry is assembled by ESC …

Mammary stem/progenitor cells (MaSCs) maintain self-renewal of the mammary epithelium
during puberty and pregnancy. DNA methylation provides a potential epigenetic mechanism …

Hematologic malignancies are one of the most common cancers, and the incidence has
been rising in recent decades. The clinical and molecular features of hematologic …

Lung cancer is a leading cause of cancer-related mortality worldwide, and is classically
divided into two major histological subtypes: non-small-cell lung cancer (NSCLC) and small …

Mechanisms-of-resistance to decitabine and 5-azacytidine, mainstay treatments for myeloid
malignancies, require investigation and countermeasures. Both are nucleoside analog pro …

Mixed lineage leukemia (MLL)-fusion proteins can induce acute myeloid leukemias (AMLs)
from either hematopoietic stem cells (HSCs) or granulocyte–macrophage progenitors …

Current hypotheses suggest that tumors originate from cells that carry out a process of
“malignant reprogramming” driven by genetic and epigenetic alterations. Multiples studies …

Acute myeloid leukemia (AML) is a heterogeneous disease that is characterized by distinct
cytogenetic or genetic abnormalities. Recent discoveries in cancer epigenetics …