The flexibility of the epigenome has generated an enticing argument to explore its reversion
through pharmacological treatments as a strategy to ameliorate disease phenotypes. All …

Background Modulating the epigenome has long been considered a potential opportunity
for therapeutic intervention in numerous disease areas with several approved therapies …

Terahertz radiation has significant potential in medical diagnosis and treatment because its
frequency range corresponds to the characteristic energy of biomolecular motion …

In recent years, cancer genomics has provided new insights into genetic alterations and
signaling pathways involved in thyroid cancer. However, the picture of the molecular …

Tissue inhibitor of metalloproteinase-3 (TIMP-3), a secreted glycoprotein, plays an important
role in carcinogenesis. It can bind to many proteinases to suppress their activity and thus …

Recent studies have uncovered an important role for RNA modifications in gene expression
regulation, which led to the birth of the epitranscriptomics field. It is now acknowledged that …

DNA methylation is a pivotal epigenetic modification of DNA that regulates gene expression.
Abnormal regulation of gene expression is closely related to carcinogenesis, which is why …

Background The mechanism of tumor immune escape and progression in colorectal cancer
(CRC) is widely investigated in-vitro to help understand and identify agents that might play a …

The secreted frizzled-related protein 5 gene (SFRP5) that antagonize the Wnt/β-catenin
signaling is frequently inactivated by promoter methylation and oncogenic activation of the …

The purpose of this study was to develop lipid drug conjugate (LDC) nanoparticles of
decitabine (DCB) using stearic acid as a lipid to increase the permeability of the drug along …