Progress in stem cell therapy for spinal cord injury

L Gao, Y Peng, W Xu, P He, T Li, X Lu… - Stem Cells …, 2020 - Wiley Online Library
Background. Spinal cord injury (SCI) is one of the serious neurological diseases that occur
in young people with high morbidity and disability. However, there is still a lack of effective …

Concise review: laying the groundwork for a first-in-human study of an induced pluripotent stem cell-based intervention for spinal cord injury

O Tsuji, K Sugai, R Yamaguchi, S Tashiro… - Stem …, 2019 - academic.oup.com
There have been numerous attempts to develop stem cell transplantation approaches to
promote the regeneration of spinal cord injury (SCI). Our multicenter team is currently …

[HTML][HTML] First-in-human clinical trial of transplantation of iPSC-derived NS/PCs in subacute complete spinal cord injury: Study protocol

K Sugai, M Sumida, T Shofuda, R Yamaguchi… - Regenerative …, 2021 - Elsevier
Introduction Our group has conducted extensive basic and preclinical studies of the use of
human induced pluripotent cell (iPSC)-derived neural stem/progenitor cell (hiPSC-NS/PC) …

[HTML][HTML] Modulation by DREADD reveals the therapeutic effect of human iPSC-derived neuronal activity on functional recovery after spinal cord injury

T Kitagawa, N Nagoshi, Y Kamata, M Kawai, K Ago… - Stem cell reports, 2022 - cell.com
Transplantation of neural stem/progenitor cells (NS/PCs) derived from human induced
pluripotent stem cells (hiPSCs) is considered to be a promising therapy for spinal cord injury …

[HTML][HTML] Long-term selective stimulation of transplanted neural stem/progenitor cells for spinal cord injury improves locomotor function

M Kawai, K Imaizumi, M Ishikawa, S Shibata… - Cell Reports, 2021 - cell.com
In cell transplantation therapy for spinal cord injury (SCI), grafted human induced pluripotent
stem cell-derived neural stem/progenitor cells (hiPSC-NS/PCs) mainly differentiate into …

How can clinical safety and efficacy concerns in stem cell therapy for spinal cord injury be overcome?

N Hejrati, R Wong, M Khazaei… - Expert Opinion on …, 2023 - Taylor & Francis
Introduction Spinal cord injury (SCI) can lead to severe neurological dysfunction. Despite
scientific and medical advances, clinically effective regenerative therapies including stem …

[HTML][HTML] Cell therapy for spinal cord injury using induced pluripotent stem cells

N Nagoshi, O Tsuji, M Nakamura, H Okano - Regenerative therapy, 2019 - Elsevier
For the past few decades, spinal cord injury (SCI) has been believed to be an incurable
traumatic condition, but with recent developments in stem cell biology, the field of …

[HTML][HTML] Prevention of tumor risk associated with the reprogramming of human pluripotent stem cells

K Wuputra, CC Ku, DC Wu, YC Lin, S Saito… - Journal of Experimental …, 2020 - Springer
Human pluripotent embryonic stem cells have two special features: self-renewal and
pluripotency. It is important to understand the properties of pluripotent stem cells and …

Selective ablation of tumorigenic cells following human induced pluripotent stem cell-derived neural stem/progenitor cell transplantation in spinal cord injury

K Kojima, H Miyoshi, N Nagoshi… - Stem Cells …, 2019 - academic.oup.com
Tumorigenesis is an important problem that needs to be addressed in the field of human
stem/progenitor cell transplantation for the treatment of subacute spinal cord injury (SCI) …

Neural stem cell therapies for spinal cord injury repair: an update on recent preclinical and clinical advances

SM Hosseini, B Borys, S Karimi-Abdolrezaee - Brain, 2024 - academic.oup.com
Traumatic spinal cord injury (SCI) is a leading cause of lifelong disabilities. Permanent
sensory, motor and autonomic impairments after SCI are substantially attributed to …