Progress in stem cell therapy for spinal cord injury
L Gao, Y Peng, W Xu, P He, T Li, X Lu… - Stem Cells …, 2020 - Wiley Online Library
Background. Spinal cord injury (SCI) is one of the serious neurological diseases that occur
in young people with high morbidity and disability. However, there is still a lack of effective …
in young people with high morbidity and disability. However, there is still a lack of effective …
Concise review: laying the groundwork for a first-in-human study of an induced pluripotent stem cell-based intervention for spinal cord injury
O Tsuji, K Sugai, R Yamaguchi, S Tashiro… - Stem …, 2019 - academic.oup.com
There have been numerous attempts to develop stem cell transplantation approaches to
promote the regeneration of spinal cord injury (SCI). Our multicenter team is currently …
promote the regeneration of spinal cord injury (SCI). Our multicenter team is currently …
[HTML][HTML] First-in-human clinical trial of transplantation of iPSC-derived NS/PCs in subacute complete spinal cord injury: Study protocol
K Sugai, M Sumida, T Shofuda, R Yamaguchi… - Regenerative …, 2021 - Elsevier
Introduction Our group has conducted extensive basic and preclinical studies of the use of
human induced pluripotent cell (iPSC)-derived neural stem/progenitor cell (hiPSC-NS/PC) …
human induced pluripotent cell (iPSC)-derived neural stem/progenitor cell (hiPSC-NS/PC) …
[HTML][HTML] Modulation by DREADD reveals the therapeutic effect of human iPSC-derived neuronal activity on functional recovery after spinal cord injury
T Kitagawa, N Nagoshi, Y Kamata, M Kawai, K Ago… - Stem cell reports, 2022 - cell.com
Transplantation of neural stem/progenitor cells (NS/PCs) derived from human induced
pluripotent stem cells (hiPSCs) is considered to be a promising therapy for spinal cord injury …
pluripotent stem cells (hiPSCs) is considered to be a promising therapy for spinal cord injury …
[HTML][HTML] Long-term selective stimulation of transplanted neural stem/progenitor cells for spinal cord injury improves locomotor function
In cell transplantation therapy for spinal cord injury (SCI), grafted human induced pluripotent
stem cell-derived neural stem/progenitor cells (hiPSC-NS/PCs) mainly differentiate into …
stem cell-derived neural stem/progenitor cells (hiPSC-NS/PCs) mainly differentiate into …
How can clinical safety and efficacy concerns in stem cell therapy for spinal cord injury be overcome?
Introduction Spinal cord injury (SCI) can lead to severe neurological dysfunction. Despite
scientific and medical advances, clinically effective regenerative therapies including stem …
scientific and medical advances, clinically effective regenerative therapies including stem …
[HTML][HTML] Cell therapy for spinal cord injury using induced pluripotent stem cells
For the past few decades, spinal cord injury (SCI) has been believed to be an incurable
traumatic condition, but with recent developments in stem cell biology, the field of …
traumatic condition, but with recent developments in stem cell biology, the field of …
[HTML][HTML] Prevention of tumor risk associated with the reprogramming of human pluripotent stem cells
K Wuputra, CC Ku, DC Wu, YC Lin, S Saito… - Journal of Experimental …, 2020 - Springer
Human pluripotent embryonic stem cells have two special features: self-renewal and
pluripotency. It is important to understand the properties of pluripotent stem cells and …
pluripotency. It is important to understand the properties of pluripotent stem cells and …
Selective ablation of tumorigenic cells following human induced pluripotent stem cell-derived neural stem/progenitor cell transplantation in spinal cord injury
K Kojima, H Miyoshi, N Nagoshi… - Stem Cells …, 2019 - academic.oup.com
Tumorigenesis is an important problem that needs to be addressed in the field of human
stem/progenitor cell transplantation for the treatment of subacute spinal cord injury (SCI) …
stem/progenitor cell transplantation for the treatment of subacute spinal cord injury (SCI) …
Neural stem cell therapies for spinal cord injury repair: an update on recent preclinical and clinical advances
SM Hosseini, B Borys, S Karimi-Abdolrezaee - Brain, 2024 - academic.oup.com
Traumatic spinal cord injury (SCI) is a leading cause of lifelong disabilities. Permanent
sensory, motor and autonomic impairments after SCI are substantially attributed to …
sensory, motor and autonomic impairments after SCI are substantially attributed to …