Multi-omics integration in the age of million single-cell data
An explosion in single-cell technologies has revealed a previously underappreciated
heterogeneity of cell types and novel cell-state associations with sex, disease, development …
heterogeneity of cell types and novel cell-state associations with sex, disease, development …
[HTML][HTML] Modelling metabolic diseases and drug response using stem cells and organoids
Metabolic diseases, including obesity, diabetes mellitus and cardiovascular disease, are a
major threat to health in the modern world, but efforts to understand the underlying …
major threat to health in the modern world, but efforts to understand the underlying …
Epigenomic and transcriptomic analyses define core cell types, genes and targetable mechanisms for kidney disease
More than 800 million people suffer from kidney disease, yet the mechanism of kidney
dysfunction is poorly understood. In the present study, we define the genetic association with …
dysfunction is poorly understood. In the present study, we define the genetic association with …
[HTML][HTML] Multimodal single cell sequencing implicates chromatin accessibility and genetic background in diabetic kidney disease progression
The proximal tubule is a key regulator of kidney function and glucose metabolism. Diabetic
kidney disease leads to proximal tubule injury and changes in chromatin accessibility that …
kidney disease leads to proximal tubule injury and changes in chromatin accessibility that …
Mapping the genetic architecture of human traits to cell types in the kidney identifies mechanisms of disease and potential treatments
The functional interpretation of genome-wide association studies (GWAS) is challenging due
to the cell-type-dependent influences of genetic variants. Here, we generated …
to the cell-type-dependent influences of genetic variants. Here, we generated …
[HTML][HTML] A single genetic locus controls both expression of DPEP1/CHMP1A and kidney disease development via ferroptosis
Genome-wide association studies (GWAS) have identified loci for kidney disease, but the
causal variants, genes, and pathways remain unknown. Here we identify two kidney disease …
causal variants, genes, and pathways remain unknown. Here we identify two kidney disease …
Epigenetic mechanisms in diabetic vascular complications and metabolic memory: the 2020 Edwin Bierman Award Lecture
R Natarajan - Diabetes, 2021 - Am Diabetes Assoc
Macrovascular complications such as atherosclerosis, myocardial infarction and stroke, and
microvascular complications such as nephropathy, retinopathy, and neuropathy are the …
microvascular complications such as nephropathy, retinopathy, and neuropathy are the …
[HTML][HTML] Transcriptome-wide association analysis identifies DACH1 as a kidney disease risk gene that contributes to fibrosis
Genome-wide association studies (GWAS) for kidney function identified hundreds of risk
regions; however, the causal variants, target genes, cell types, and disease mechanisms …
regions; however, the causal variants, target genes, cell types, and disease mechanisms …
Donor and recipient polygenic risk scores influence the risk of post-transplant diabetes
A Shaked, BL Loza, E Van Loon, KM Olthoff, W Guan… - Nature Medicine, 2022 - nature.com
Post-transplant diabetes mellitus (PTDM) reduces allograft and recipient life span. Polygenic
risk scores (PRSs) show robust association with greater risk of developing type 2 diabetes …
risk scores (PRSs) show robust association with greater risk of developing type 2 diabetes …
[HTML][HTML] Emerging role of long non-coding RNAs in diabetic vascular complications
VS Tanwar, MA Reddy, R Natarajan - Frontiers in endocrinology, 2021 - frontiersin.org
Chronic metabolic disorders such as obesity and diabetes are associated with accelerated
rates of macrovascular and microvascular complications, which are leading causes of …
rates of macrovascular and microvascular complications, which are leading causes of …