The role of the aryl hydrocarbon receptor (AHR) in immune and inflammatory diseases
The aryl hydrocarbon receptor (AHR) is a nuclear receptor that modulates the response to
environmental stimuli. It was recognized historically for its role in toxicology but, in recent …
environmental stimuli. It was recognized historically for its role in toxicology but, in recent …
The role of cigarette smoke-induced epigenetic alterations in inflammation
D Zong, X Liu, J Li, R Ouyang, P Chen - Epigenetics & Chromatin, 2019 - Springer
Background Exposure to cigarette smoke (CS) is a major threat to human health worldwide.
It is well established that smoking increases the risk of respiratory diseases, cardiovascular …
It is well established that smoking increases the risk of respiratory diseases, cardiovascular …
[PDF][PDF] DNA methylation in newborns and maternal smoking in pregnancy: genome-wide consortium meta-analysis
Epigenetic modifications, including DNA methylation, represent a potential mechanism for
environmental impacts on human disease. Maternal smoking in pregnancy remains an …
environmental impacts on human disease. Maternal smoking in pregnancy remains an …
Hypomethylation of smoking-related genes is associated with future lung cancer in four prospective cohorts
DNA hypomethylation in certain genes is associated with tobacco exposure but it is
unknown whether these methylation changes translate into increased lung cancer risk. In an …
unknown whether these methylation changes translate into increased lung cancer risk. In an …
DNA methylation changes of whole blood cells in response to active smoking exposure in adults: a systematic review of DNA methylation studies
X Gao, M Jia, Y Zhang, LP Breitling, H Brenner - Clinical epigenetics, 2015 - Springer
Active smoking is a major preventable public health problem and an established critical
factor for epigenetic modification. In this systematic review, we identified 17 studies …
factor for epigenetic modification. In this systematic review, we identified 17 studies …
Smoking induces coordinated DNA methylation and gene expression changes in adipose tissue with consequences for metabolic health
Background Tobacco smoking is a risk factor for multiple diseases, including cardiovascular
disease and diabetes. Many smoking-associated signals have been detected in the blood …
disease and diabetes. Many smoking-associated signals have been detected in the blood …
“GrimAge,” an epigenetic predictor of mortality, is accelerated in major depressive disorder
Major depressive disorder (MDD) is associated with premature mortality and is an
independent risk factor for a broad range of diseases, especially those associated with …
independent risk factor for a broad range of diseases, especially those associated with …
AHRR (cg05575921) hypomethylation marks smoking behaviour, morbidity and mortality
Rationale and objectives Self-reported smoking underestimates disease risk. Smoking
affects DNA methylation, in particular the cg05575921 site in the aryl hydrocarbon receptor …
affects DNA methylation, in particular the cg05575921 site in the aryl hydrocarbon receptor …
Maternal smoking during pregnancy induces persistent epigenetic changes into adolescence, independent of postnatal smoke exposure and is associated with …
Background: Several studies have shown effects of current and maternal smoking during
pregnancy on DNA methylation of CpG sites in newborns and later in life. Here, we …
pregnancy on DNA methylation of CpG sites in newborns and later in life. Here, we …