The minfi package is widely used for analyzing Illumina DNA methylation array data. Here
we describe modifications to the minfi package required to support the …

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease with an estimated
heritability between 40 and 50%. DNA methylation patterns can serve as proxies of (past) …

Although it is assumed that epigenetic mechanisms, such as changes in DNA methylation
(DNAm), underlie the relationship between adverse intrauterine conditions and adult …

The methylome is subject to genetic and environmental effects. Their impact may depend on
sex and age, resulting in sex-and age-related physiological variation and disease …

Mutations in the epigenetic modifier TET2 are frequent in myeloid malignancies and clonal
hematopoiesis of indeterminate potential (CHIP) and clonal cytopenia of undetermined …

Motivation DNA methylation datasets are growing ever larger both in sample size and
genome coverage. Novel computational solutions are required to efficiently handle these …

We show that epigenome-and transcriptome-wide association studies (EWAS and TWAS)
are prone to significant inflation and bias of test statistics, an unrecognized phenomenon …

Nicotinamide adenine dinucleotide (NAD+) precursor nicotinamide riboside (NR) has
emerged as a promising compound to improve obesity-associated mitochondrial dysfunction …

Sézary syndrome (Sz) is a malignancy of skin-homing CD4+ memory T cells that is clinically
characterized by erythroderma, lymphadenopathy, and blood involvement. Distinction of Sz …

Background The well-established association of chronological age with changes in DNA
methylation is primarily founded on the analysis of large sets of blood samples, while …