We now know that cancer is many different diseases, with great variation even within a
single histological subtype. With the current emphasis on developing personalized …

In each somatic cell of a female mammal one X chromosome is transcriptionally silenced via
X-chromosome inactivation (XCI), initiating early in development. Although XCI events are …

Understanding the molecular programs that guide differentiation during development is a
major challenge. Here, we introduce Waddington-OT, an approach for studying …

Summary Oct4, Sox2, Klf4, and cMyc (OSKM) reprogram somatic cells to pluripotency. To
gain a mechanistic understanding of their function, we mapped OSKM-binding, stage …

Differentiating somatic cells are progressively restricted to specialized functions during
ontogeny, but they can be experimentally directed to form other cell types, including those …

X-chromosome inactivation (XCI) is a developmentally associated process that evolved in
mammals to enable gene dosage compensation between XX and XY individuals. In …

During development, cells transition from a pluripotent to a differentiated state, generating all
the different types of cells in the body. Development is generally considered an irreversible …

Nuclear compartments have diverse roles in regulating gene expression, yet the molecular
forces and components that drive compartment formation remain largely unclear. The long …

Background Unlike autosomal tumor suppressors, X-linked tumor suppressors can be
inactivated by a single hit due to X-chromosome inactivation (XCI). Here, we argue that …

A hallmark of chromosome organization is the partition into transcriptionally active A and
repressed B compartments, and into topologically associating domains (TADs). Both …