Single-cell transcriptomics reveals dynamic role of smooth muscle cells and enrichment of immune cell subsets in human abdominal aortic aneurysms
Objective: To determine cell-specific gene expression profiles that contribute to development
of abdominal aortic aneurysms (AAAs). Background: AAAs represent the most common …
of abdominal aortic aneurysms (AAAs). Background: AAAs represent the most common …
[HTML][HTML] Critical role of ADAMTS-4 in the development of sporadic aortic aneurysm and dissection in mice
Sporadic aortic aneurysm and dissections (AADs) are common vascular diseases that carry
a high mortality rate. ADAMTS-4 (a disintegrin-like and metalloproteinase with …
a high mortality rate. ADAMTS-4 (a disintegrin-like and metalloproteinase with …
Parallel murine and human aortic wall genomics reveals metabolic reprogramming as key driver of abdominal aortic aneurysm progression
G Gäbel, BH Northoff, A Balboa… - Journal of the …, 2021 - Am Heart Assoc
Background While numerous interventions effectively interfered with abdominal aortic
aneurysm (AAA) formation/progression in preclinical models, none of the successes …
aneurysm (AAA) formation/progression in preclinical models, none of the successes …
Necroptosis in cardiovascular disease-a new therapeutic target
Contrary to the apoptosis-necrosis binary view of cell death, recent experimental evidence
demonstrates that several forms of necrosis, represented by necroptosis, are regulated or …
demonstrates that several forms of necrosis, represented by necroptosis, are regulated or …
Systematic review and meta-analysis of the effects of statin therapy on abdominal aortic aneurysms
CP Twine, IM Williams - Journal of British Surgery, 2011 - academic.oup.com
Background The aim was to investigate the effects of statin therapy on abdominal aortic
aneurysm (AAA) disease. Methods PubMed, the Cochrane Library, Embase and …
aneurysm (AAA) disease. Methods PubMed, the Cochrane Library, Embase and …
[HTML][HTML] Hypoperfusion of the adventitial vasa vasorum develops an abdominal aortic aneurysm
The aortic wall is perfused by the adventitial vasa vasorum (VV). Tissue hypoxia has
previously been observed as a manifestation of enlarged abdominal aortic aneurysms …
previously been observed as a manifestation of enlarged abdominal aortic aneurysms …
[PDF][PDF] A randomized trial of exercise training in abdominal aortic aneurysm disease
J Myers, M Mcelrath, A Jaffe, K Smith… - Medicine & Science in …, 2014 - cardiology.org
METHODS Study design, recruitment, and randomization. One hundred and forty subjects
with small AAA, defined as an aortic diameter between 2.5 and 5.0 cm, were recruited from …
with small AAA, defined as an aortic diameter between 2.5 and 5.0 cm, were recruited from …
Overview of aortic aneurysm management in the endovascular era
A Calero, KA Illig - Seminars in vascular surgery, 2016 - Elsevier
Management of aortic aneurysm disease has changed in the endovascular era, with the
majority of patients opting for stent-graft repair of abdominal and thoracic aneurysms. An …
majority of patients opting for stent-graft repair of abdominal and thoracic aneurysms. An …
Mast cells: important players in the orchestrated pathogenesis of abdominal aortic aneurysms
J Swedenborg, MI Mäyränpää… - … thrombosis, and vascular …, 2011 - Am Heart Assoc
Mast cells (MCs) regulate inflammation and immunity. Their granular content includes
heparin, histamine, and several enzymes (tryptase, chymase, carboxypeptidase, and …
heparin, histamine, and several enzymes (tryptase, chymase, carboxypeptidase, and …
Simulation of abdominal aortic aneurysm growth with updating hemodynamic loads using a realistic geometry
A Sheidaei, SC Hunley, S Zeinali-Davarani… - Medical engineering & …, 2011 - Elsevier
Advances in modeling vascular tissue growth and remodeling (G&R) as well as medical
imaging usher in a great potential for integrative computational mechanics to revolutionize …
imaging usher in a great potential for integrative computational mechanics to revolutionize …