Abdominal aortic aneurysm (AAA) remains the second most frequent vascular disease with
high mortality but has no approved medical therapy. We investigated the direct role of apelin …

Aortic aneurysm is dilation of the aorta primarily due to degradation of the aortic wall
extracellular matrix (ECM). Tissue inhibitors of metalloproteinases (TIMPs) inhibit matrix …

Aortic aneurysm (AA) is a vascular disorder characterized pathologically by inflammatory
cell invasion and extracellular matrix (ECM) degradation. It is known that regulation of the …

Background The progression of abdominal aortic aneurysm (AAA) involves a sustained
influx of proinflammatory macrophages, which exacerbate tissue injury by releasing …

Granzyme B (GZMB) is a serine protease that is abundantly expressed in advanced human
atherosclerotic lesions and may contribute to plaque instability. Perforin is a pore-forming …

Tew GA, Moss J, Crank H, Mitchell PA, Nawaz S. Endurance exercise training in patients
with small abdominal aortic aneurysm: a randomized controlled pilot study. OBJECTIVE: To …

Aims Phenotypic switching of vascular smooth muscle cells (VSMCs) is essential for the
formation of abdominal aortic aneurysms (AAAs). MicroRNA-23b (miR-23b) has recently …

Objective—Abdominal aortic aneurysm is caused by the accumulation of inflammatory cells
in the aortic wall. Our recent studies demonstrated that inhibition of Notch signaling …

Objective—The renin–angiotensin system is thought to play a pivotal role in the
pathogenesis of abdominal aortic aneurysms (AAAs). However, effects of angiotensin …

Despite rapid expansion of our knowledge of vascular adaptation, developing patient-
specific models of diseased arteries is still an open problem. In this study, we extend existing …