Mesenchymal stem cells (MSCs) exhibit therapeutic benefits on aortic aneurysm (AA);
however, the molecular mechanisms are not fully understood. The current study aimed to …

Toll-like receptor (TLR) family plays a key role in innate immunity and various inflammatory
responses. TLR4, one of the well-characterized pattern-recognition receptors, can be …

Chronic inflammation is a hallmark of age-related cardiovascular and pulmonary diseases.
Granzymes are a family of serine proteases that have been traditionally viewed as initiators …

Abdominal aortic aneurysm (AAA) remains a fatal disease in the elderly. Currently, no drugs
can be clinically used for AAA therapy. Considering the pivotal role of neutrophils in the …

Objective—Angiotensin-converting enzyme 2 (ACE2) cleaves angiotensin II (AngII) to form
angiotensin-(1–7)(Ang-(1–7)), which generally opposes effects of AngII. AngII infusion into …

Objective: Excessive prostaglandin E2 production is a hallmark of abdominal aortic
aneurysm (AAA). Enhanced expression of prostaglandin E2 receptor EP4 (prostaglandin E …

Background There is no proven medical approach to attenuating expansion and rupture of
abdominal aortic aneurysms (AAAs). One approach that is currently being investigated is the …

Objective/background The impact of post-operative complications in abdominal aortic
aneurysm (AAA) surgery is substantial, and increases with age and concomitant co …

Abdominal aortic aneurysms (AAAs) expand as a consequence of extracellular matrix
destruction, and vascular smooth muscle cell (VSMC) depletion. Transforming growth factor …

Purpose In this study we investigate the relationship between 18 F-fluorodeoxyglucose
(FDG) metabolism and future aneurysm expansion measured by serial duplex ultrasound …