There is a large and growing body of evidence on the health benefits of engagement in
leisure activities (voluntary, enjoyable non-work activities, such as hobbies, arts …

Frailty is thought to be one of the most serious public health challenges of the twentyfirst
century. 1 All older adults are at risk for developing frailty, and it is associated with many …

Background To date, few studies have focused on examining either the direct or indirect
effect of physical frailty on cognitive impairment. This study aimed to investigate the …

China and the world are facing severe population aging and an increasing burden of age-
related diseases. Aging of the brain causes major age-related brain diseases, such as …

Degeneration of photoreceptors in age-related macular degeneration (AMD) is associated
with oxidative stress due to the intense aerobic metabolism of rods and cones that if not …

Frailty is a complex geriatric syndrome with multifactorial associated mechanisms that need
to be examined more deeply to help reverse the adverse health-related outcomes. Specific …

While physical frailty has been recognized as a clinical entity for some time, the concept of
cognitive frailty (CF) is now gaining increasing attention in the geriatrics research …

Introduction Frailty and impaired cognitive functioning often co-occur in older adults and are
associated with adverse health outcomes. However, their relationship is unclear. This study …

Background Sleep status, including sleep quality and nap duration, may be associated with
frailty and cognitive impairment in older adults. Older adults living in nursing homes may be …

Frailty is considered a multidimensional geriatric syndrome, manifested by the accumulation
of age-associated deficits. The consequences of frailty transitions are still understudied. This …