The immune system and cancer have a complex relationship with the immune system
playing a dual role in tumor development. The effector cells of the immune system can …

Over the last decade, the active role of the microenvironment in the pathogenesis of B cell
lymphomas has been recognized, delivering signals that favor clonal expansion and drug …

Purpose Although CD49d is an unfavorable prognostic marker in chronic lymphocytic
leukemia (CLL), definitive validation evidence is lacking. A worldwide multicenter analysis …

Intrinsic factors such as genetic lesions, anti-apoptotic proteins, and aberrant signaling
networks within leukemia cells have long been the main focus of chronic lymphocytic …

The treatment landscape for patients with chronic lymphocytic leukemia (CLL) has changed
considerably with the introduction of very effective oral targeted therapies (such as ibrutinib …

Aberrant expression of microRNAs has been recently associated with chronic lymphocytic
leukemia (CLL) outcome. Although disease evolution can be predicted by several …

BACKGROUND: The objective of the current study was to follow up the results of phase 1
testing by evaluating the clinical efficacy of the green tea extract Polyphenon E for patients …

Mantle cell lymphoma (MCL) is characterized by an early, widespread dissemination and
residual disease after conventional treatment, but the mechanisms responsible for …

Rai and Binet staging systems are important to predict the outcome of patients with chronic
lymphocytic leukemia (CLL) but do not reflect the biologic diversity of the disease nor predict …

BACKGROUND Although hypogammaglobulinemia is a well recognized complication in
patients with chronic lymphocytic leukemia (CLL), its prevalence at the time of CLL …