DNA methylation (5-methylcytosine, 5mC) is a major form of DNA modification in the
mammalian genome that plays critical roles in chromatin structure and gene expression. In …

Phenotypic and functional heterogeneity is one of the hallmarks of human cancers. Tumor
genotype variations among tumors within different patients are known as interpatient …

Background Friend leukemia virus integration 1 (FLI1), an ETS transcription factor family
member, acts as an oncogenic driver in hematological malignancies and promotes tumor …

DNA methylation plays an important role in gene expression, chromatin stability, and genetic
imprinting. In mammals, DNA methylation patterns are written and regulated by DNA …

Osteosarcoma (OS) is a bone tumor of mesenchymal origin, most frequently occurring
during the rapid growth phase of long bones, and usually located in the epiphyseal growth …

In mammals, DNA methylation is introduced by the DNMT1, DNMT3A and DNMT3B
methyltransferases, which are all large multi-domain proteins containing a catalytic C …

MicroRNA (miRNA) biogenesis initiates co-transcriptionally, but how the Microprocessor
machinery pinpoints the locations of short precursor miRNA sequences within long flanking …

Background Pancreatic cancer or pancreatic ductal adenocarcinoma (PDAC) is one of the
most devastating cancer types with a 5-year survival rate of only 9%. PDAC is one of the …

The biological function of PRMT5 remains poorly understood in cervical cancer metastasis.
Here, we report that PRMT5 physically associates with the transcription factor Snail and the …

Acute myeloid leukemia (AML) is a hematological malignancy characterized by cytogenetic
and genomic alterations. Up to now, combination chemotherapy remains the standard …