Common causes of hearing loss in humans-exposure to loud noise or ototoxic drugs and
aging-often damage sensory hair cells, reflected as elevated thresholds on the clinical …

Animal studies demonstrate that noise exposure can permanently damage the synapses
between inner hair cells and auditory nerve fibers, even when outer hair cells are intact and …

Cochlear synaptic loss, rather than hair cell death, is the earliest sign of damage in both
noise-and age-related hearing impairment (;). Here, we compare cochlear aging after two …

Dramatic results from recent animal experiments show that noise exposure can cause a
selective loss of high-threshold auditory nerve fibers without affecting absolute sensitivity …

Cochlear synaptopathy can result from various insults, including acoustic trauma, aging,
ototoxicity, or chronic conductive hearing loss. For example, moderate noise exposure in …

Evidence from animal and human studies suggests that moderate acoustic exposure,
causing only transient threshold elevation, can nonetheless cause “hidden hearing loss” that …

Objective: To review basic and clinical findings relevant to defining temporary (TTS) and
permanent (PTS) threshold shifts and their sequelae. Data Sources: Relevant scientific …

Clinical audiometry has long focused on determining the detection thresholds for pure tones,
which depend on intact cochlear mechanics and hair cell function. Yet many listeners with …

Aging listeners, even in the absence of overt hearing loss measured as changes in hearing
thresholds, often experience impairments processing temporally complex sounds such as …

In acquired sensorineural hearing loss, such as that produced by noise or aging, there can
be massive loss of the synaptic connections between cochlear sensory cells and primary …