Aging of the brain can manifest itself as a memory and cognitive decline, which has been
shown to frequently coincide with changes in the structural plasticity of dendritic spines …

Epigenetic modifications are increasingly recognized to play a role in the etiology and
pathophysiology of schizophrenia and other psychiatric disorders with developmental …

DNA methylation is a critical regulatory mechanism implicated in development, learning,
memory, and disease in the human brain. Here we have elucidated DNA methylation …

Human DNA methylation data have been used to develop biomarkers of ageing, referred to
as 'epigenetic clocks', which have been widely used to identify differences between …

Epigenetic lesions that disrupt regulatory elements represent potential cancer drivers.
However, we lack experimental models for validating their tumorigenic impact. Here, we …

Human-specific genomic changes contribute to the unique functionalities of the human
brain,,,–. The cellular heterogeneity of the human brain, and the complex regulation of gene …

Schizophrenia (SCZ) is a debilitating neuropsychiatric disorder with high heritability and
complex inheritance. In the past decade, successful identification of numerous susceptibility …

Schizophrenia is a neuropsychiatric disorder characterized by dissociation of thoughts, idea,
identity, and emotions. It has no central pathophysiological mechanism and precise …

The chromatin landscape of human brain cells encompasses key information to
understanding brain function. Here we use ATAC-seq to profile the chromatin structure in …

Oligodendrocytes provide metabolic and functional support to neuronal cells, rendering
them key players in the functioning of the central nervous system. Oligodendrocytes need to …