Rapid progress in identifying biomarkers that are hallmarks of disease has increased
demand for high-performance detection technologies. Implementation of electrochemical …

Epigenetic modifications mainly includes nucleic modifications and histone modifications,
which play crucial role in biological processes, such as gene and microRNA expression …

Visual one-step simultaneous detection of low-abundance methylation is a crucial challenge
in early cancer diagnosis in a simple manner. Through the design of a closed split bipolar …

With recent insight into the mechanisms involved in diseases, such as cardiovascular
disease, cancer, stroke, neurodegenerative diseases, and diabetes, more efficient modes of …

DNA methylation is a key factor in the pathogenesis of gene expression diseases or
malignancies. Thus, it has become a significant biomarker for the diagnosis and prognosis …

We have developed a novel biosensor platform for colorimetric detection of active DNA
methyltransferase/glycosylase based on terminal protection of the DNA-gold nanoparticle …

Methylation is an important epigenetic DNA modification that governs gene expression. The
genomic level of methylated DNA and its derivatives may serve as important indicators for …

A novel hybridization chain reaction-based branched rolling circle amplification combining
the fabrication of multi-HRP-capped MNPs is developed for chemiluminescence detection of …

Magnetic nanoparticles (MNPs) are widely used for the immobilization of enzyme owing to
the unique properties such as good biocompatibility and rapid separation. Herein, we used …

DNA methylation is an essential genomic epigenetic behavior in both eukaryotes and
prokaryotes. Deregulation of DNA methyltransferase (Dam MTase) can change the DNA …