Therapeutic and toxic blood concentrations of nearly 1,000 drugs and other xenobiotics

M Schulz, S Iwersen-Bergmann, H Andresen… - Critical care, 2012 - Springer
Introduction In order to assess the significance of drug levels measured in intensive care
medicine, clinical and forensic toxicology, as well as for therapeutic drug monitoring, it is …

Therapeutic and toxic blood concentrations of more than 800 drugs and other xenobiotics

M Schulz, A Schmoldt - Die Pharmazie-An International Journal …, 2003 - ingentaconnect.com
In order to assess the significance of drug levels measured in clinical and forensic toxicology
as well as for Therapeutic Drug Monitoring (TDM) it is essential that good collections of data …

Optimization of polysaccharides extraction from watermelon rinds: Structure, functional and biological activities

MB Romdhane, A Haddar, I Ghazala, KB Jeddou… - Food Chemistry, 2017 - Elsevier
In the present work, optimization of hot water extraction, structural characteristics, functional
properties, and biological activities of polysaccharides extracted from watermelon rinds …

Angiotensin-converting enzyme inhibitor–associated elevations in serum creatinine: is this a cause for concern?

GL Bakris, MR Weir - Archives of internal medicine, 2000 - jamanetwork.com
Background Reducing the actions of the renin-angiotensin-aldosterone system with
angiotensin-converting enzyme inhibitors (ACEIs) slows nephropathy progression in …

Clarification of terminology in drug safety

JK Aronson, RE Ferner - Drug safety, 2005 - Springer
Nomenclature surrounding drug safety needs to be clear and unambiguous, so that patients,
prescribers, manufacturers, and regulators can all understand each other. In particular, it …

Joining the DoTS: new approach to classifying adverse drug reactions

JK Aronson, RE Ferner - Bmj, 2003 - bmj.com
The pharmacological classification of adverse drug reactions whose causality has been
established currently rests on the perceived dose dependence and predictability of the …

Effect of Powdered Fermented Milk with Lactobacillus helveticus on Subjects with High-Normal Blood Pressure or Mild Hypertension

K Aihara, O Kajimoto, H Hirata… - Journal of the …, 2005 - Taylor & Francis
Objective: Two tripeptides (Val-Pro-Pro and Ile-Pro-Pro) that have inhibitory activities for
angiotensin I-converting enzyme are produced in milk fermented with Lactobacillus …

Purification and characterization of a novel angiotensin-I converting enzyme (ACE) inhibitory peptide derived from enzymatic hydrolysate of grass carp protein

J Chen, Y Wang, Q Zhong, Y Wu, W Xia - Peptides, 2012 - Elsevier
Peptides inhibiting angiotensin-I converting enzyme (ACE, EC. 3.4. 15.1) are possible cures
of hypertension. Food-derived ACE-inhibitory peptides are particularly attractive because of …

An evaluation of risk factors for adverse drug events associated with angiotensin‐converting enzyme inhibitors

T Morimoto, TK Gandhi, JM Fiskio… - Journal of evaluation …, 2004 - Wiley Online Library
Rationale, aims and objectives To identify potential factors leading to discontinuation of
angiotensin‐converting enzyme (ACE) inhibitors because of adverse drug events. Methods …

Small molecule angiotensin converting enzyme inhibitors: A medicinal chemistry perspective

W Zheng, E Tian, Z Liu, C Zhou, P Yang… - Frontiers in …, 2022 - frontiersin.org
Angiotensin-converting enzyme (ACE), a zinc metalloprotein, is a central component of the
renin–angiotensin system (RAS). It degrades bradykinin and other vasoactive peptides …