Abstract Over 90 years ago, Otto Warburg's seminal discovery of aerobic glycolysis
established metabolic reprogramming as one of the first distinguishing characteristics of …

Tumors display reprogrammed metabolic activities that promote cancer progression. We
currently possess a limited understanding of the processes governing tumor metabolism in …

Chronic venous disease (CVD) is a multifactorial condition affecting an important
percentage of the global population. It ranges from mild clinical signs, such as …

Cancer is one of the leading causes of death globally, associated with multifactorial
pathophysiological components. In particular, genetic mutations, infection or inflammation …

Background Breast cancer is defined as a biological and molecular heterogeneous disorder
that originates from breast cells. Genetic predisposition is the most important factor giving …

Human malignant tumors are characterized by pervasive changes in the patterns of DNA
methylation. These changes include a globally hypomethylated tumor cell genome and the …

Colorectal cancer (CRC) is a leading cause of cancer death worldwide. It includes different
subtypes that differ in their clinical and prognostic features. In the past decade, in addition to …

Although DNA methylation is an important gene regulatory mechanism in mammals, its
function in arthropods remains poorly understood. Studies in eusocial insects have argued …

A DNA sequence is the hard copy of the human genome and it is a driving force in
determining the physiological processes in an organism. Concurrently, the chemical …

Stable inheritance of DNA methylation is critical for maintaining differentiated phenotypes in
multicellular organisms. We have recently identified dual mono-ubiquitylation of histone H3 …