Amino acids in cancer
Abstract Over 90 years ago, Otto Warburg's seminal discovery of aerobic glycolysis
established metabolic reprogramming as one of the first distinguishing characteristics of …
established metabolic reprogramming as one of the first distinguishing characteristics of …
Mechanisms and implications of metabolic heterogeneity in cancer
J Kim, RJ DeBerardinis - Cell metabolism, 2019 - cell.com
Tumors display reprogrammed metabolic activities that promote cancer progression. We
currently possess a limited understanding of the processes governing tumor metabolism in …
currently possess a limited understanding of the processes governing tumor metabolism in …
Understanding chronic venous disease: a critical overview of its pathophysiology and medical management
MA Ortega, O Fraile-Martínez… - Journal of clinical …, 2021 - mdpi.com
Chronic venous disease (CVD) is a multifactorial condition affecting an important
percentage of the global population. It ranges from mild clinical signs, such as …
percentage of the global population. It ranges from mild clinical signs, such as …
Nutraceuticals and cancer: Potential for natural polyphenols
J Maiuolo, M Gliozzi, C Carresi, V Musolino… - Nutrients, 2021 - mdpi.com
Cancer is one of the leading causes of death globally, associated with multifactorial
pathophysiological components. In particular, genetic mutations, infection or inflammation …
pathophysiological components. In particular, genetic mutations, infection or inflammation …
The role of epigenetic modifications in drug resistance and treatment of breast cancer
M Karami Fath, A Azargoonjahromi, A Kiani… - Cellular & Molecular …, 2022 - Springer
Background Breast cancer is defined as a biological and molecular heterogeneous disorder
that originates from breast cells. Genetic predisposition is the most important factor giving …
that originates from breast cells. Genetic predisposition is the most important factor giving …
Defining driver DNA methylation changes in human cancer
GP Pfeifer - International journal of molecular sciences, 2018 - mdpi.com
Human malignant tumors are characterized by pervasive changes in the patterns of DNA
methylation. These changes include a globally hypomethylated tumor cell genome and the …
methylation. These changes include a globally hypomethylated tumor cell genome and the …
The molecular hallmarks of the serrated pathway in colorectal cancer
Colorectal cancer (CRC) is a leading cause of cancer death worldwide. It includes different
subtypes that differ in their clinical and prognostic features. In the past decade, in addition to …
subtypes that differ in their clinical and prognostic features. In the past decade, in addition to …
The roles of human DNA methyltransferases and their isoforms in shaping the epigenome
A DNA sequence is the hard copy of the human genome and it is a driving force in
determining the physiological processes in an organism. Concurrently, the chemical …
determining the physiological processes in an organism. Concurrently, the chemical …
Two distinct modes of DNMT1 recruitment ensure stable maintenance DNA methylation
Stable inheritance of DNA methylation is critical for maintaining differentiated phenotypes in
multicellular organisms. We have recently identified dual mono-ubiquitylation of histone H3 …
multicellular organisms. We have recently identified dual mono-ubiquitylation of histone H3 …
Efficient and accurate determination of genome-wide DNA methylation patterns in Arabidopsis thaliana with enzymatic methyl sequencing
Background 5′ methylation of cytosines in DNA molecules is an important epigenetic mark
in eukaryotes. Bisulfite sequencing is the gold standard of DNA methylation detection, and …
in eukaryotes. Bisulfite sequencing is the gold standard of DNA methylation detection, and …