Pipeline to Neonatal Clinical Transformation: The Importance of Preclinical Data

SE Juul, TR Wood - Clinics in Perinatology, 2024 - perinatology.theclinics.com
We live in a time of incredible scientific and medical break throughs, ranging from new
protective vaccines for respiratory syncytial virus and other diseases, to gene editing …

Midazolam en anestesiología: Artículo de revisión

JMS Lozada, MVC Caballero - Ciencia Ecuador, 2023 - cienciaecuador.com.ec
El midazolam es un fármaco ansiolítico, anticonvulsivante, usado en la hipnosis en la
anestesia general. Además se ha evidenciado su eficacia como medicamento adyuvante en …

Effects of season, daytime, sex, and stress on the incidence, latency, frequency, severity, and duration of neonatal seizures in a rat model of birth asphyxia

R Schmidt, B Welzel, W Löscher - Epilepsy & Behavior, 2023 - Elsevier
Neonatal seizures are common in newborn infants after birth asphyxia. They occur more
frequently in male than female neonates, but it is not known whether sex also affects seizure …

Sex differences in hippocampal structural plasticity and glycosaminoglycan disaccharide levels after neonatal handling

JG Hashimoto, ML Singer, CM Goeke, F Zhang… - Experimental …, 2023 - Elsevier
In this study we investigated the effects of a neonatal handling protocol that mimics the
handling of sham control pups in protocols of neonatal exposure to brain insults on dendritic …

Bumetanide potentiates the anti-seizure and disease-modifying effects of midazolam in a noninvasive rat model of term birth asphyxia

B Welzel, M Johne, W Löscher - Epilepsy & Behavior, 2023 - Elsevier
Birth asphyxia and the resulting hypoxic-ischemic encephalopathy (HIE) are highly
associated with perinatal and neonatal death, neonatal seizures, and an adverse later-life …

[HTML][HTML] The application value of combined detection of serum il-6, ldh, s100, nse, and gfap in the early diagnosis of brain damage caused by neonatal asphyxia

B Liu, H Lan, N Gao, G Hu - Iranian Journal of Public Health, 2023 - ncbi.nlm.nih.gov
Background: We aimed to investigate the correlation and clinical significance between a
group of serum biomarkers and brain damage caused by neonatal asphyxia, and to provide …

The loop diuretic torasemide but not azosemide potentiates the anti-seizure and disease-modifying effects of midazolam in a rat model of birth asphyxia

B Welzel, R Schmidt, L Kirchhoff, M Gramer… - Epilepsy & Behavior, 2023 - Elsevier
Loop diuretics such as furosemide and bumetanide, which act by inhibiting the Na-K-2Cl
cotransporter NKCC2 at the thick ascending limb of the loop of Henle, have been shown to …

[HTML][HTML] 咪达唑仑口服溶液在患儿七氟烷麻醉术后躁动的临床应用

王琳, 高兴超, 冯立霞, 郑利艳, 邱同霞… - Advances in Clinical …, 2023 - hanspub.org
目的: 探讨咪达唑仑口服液对七氟烷麻醉儿童术后躁动, 不良反应的影响. 方法: 选择2022 年3
月至2023 年6 月日照市中心医院收治的腹部手术患儿120 例, 采用随机数字表法将患者分为3 …

[图书][B] Long-term outcome in a rat model of birth asphyxia with neonatal seizures and the impact of pharmacological intervention with midazolam

B Welzel - 2022 - elib.tiho-hannover.de
Birth asphyxia is a major cause of neonatal death and brain damage. The asphyxia-induced
hypoxic-ischemic encephalopathy (HIE) is often associated with seizures and the later-life …