Artificial intelligence to deep learning: machine intelligence approach for drug discovery
Drug designing and development is an important area of research for pharmaceutical
companies and chemical scientists. However, low efficacy, off-target delivery, time …
companies and chemical scientists. However, low efficacy, off-target delivery, time …
Advances in the development of new biomarkers for Alzheimer's disease
TO Klyucherev, P Olszewski, AA Shalimova… - Translational …, 2022 - Springer
Alzheimer's disease (AD) is a complex, heterogeneous, progressive disease and is the most
common type of neurodegenerative dementia. The prevalence of AD is expected to increase …
common type of neurodegenerative dementia. The prevalence of AD is expected to increase …
Neuropharmacological effects of quercetin: a literature-based review
Quercetin (QUR) is a natural bioactive flavonoid that has been lately very studied for its
beneficial properties in many pathologies. Its neuroprotective effects have been …
beneficial properties in many pathologies. Its neuroprotective effects have been …
Impact of natural compounds on neurodegenerative disorders: from preclinical to pharmacotherapeutics
Among the major neurodegenerative disorders (NDDs), Alzheimer's disease (AD) and
Parkinson's disease (PD), are a huge socioeconomic burden. Over many centuries, people …
Parkinson's disease (PD), are a huge socioeconomic burden. Over many centuries, people …
PPARγ/PGC1α signaling as a potential therapeutic target for mitochondrial biogenesis in neurodegenerative disorders
S Jamwal, JK Blackburn, JD Elsworth - Pharmacology & Therapeutics, 2021 - Elsevier
Neurodegenerative diseases represent some of the most devastating neurological
disorders, characterized by progressive loss of the structure and function of neurons. Current …
disorders, characterized by progressive loss of the structure and function of neurons. Current …
Computational/in silico methods in drug target and lead prediction
FE Agamah, GK Mazandu, R Hassan… - Briefings in …, 2020 - academic.oup.com
Drug-like compounds are most of the time denied approval and use owing to the
unexpected clinical side effects and cross-reactivity observed during clinical trials. These …
unexpected clinical side effects and cross-reactivity observed during clinical trials. These …
Dysfunctional mitochondria and mitophagy as drivers of Alzheimer's disease pathogenesis
A Chakravorty, CT Jetto, R Manjithaya - Frontiers in aging …, 2019 - frontiersin.org
Neurons are highly specialized post-mitotic cells that are inherently dependent on
mitochondria owing to their high bioenergetic demand. Mitochondrial dysfunction is …
mitochondria owing to their high bioenergetic demand. Mitochondrial dysfunction is …
Anthocyanins and their metabolites as therapeutic agents for neurodegenerative disease
AN Winter, PC Bickford - Antioxidants, 2019 - mdpi.com
Neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, and
amyotrophic lateral sclerosis (ALS), are characterized by the death of neurons within specific …
amyotrophic lateral sclerosis (ALS), are characterized by the death of neurons within specific …
Bacopa monnieri, a Neuroprotective Lead in Alzheimer Disease: A Review on Its Properties, Mechanisms of Action, and Preclinical and Clinical Studies
AS Abdul Manap, S Vijayabalan… - Drug target …, 2019 - journals.sagepub.com
Alzheimer disease is a neurodegenerative disease that is signified by cognitive decline,
memory loss, and erratic behavior. Till date, no cure for Alzheimer exists and the current …
memory loss, and erratic behavior. Till date, no cure for Alzheimer exists and the current …
Beneficial effects of spirulina consumption on brain health
Spirulina is a microscopic, filamentous cyanobacterium that grows in alkaline water bodies.
It is extensively utilized as a nutraceutical food supplement all over the world due to its high …
It is extensively utilized as a nutraceutical food supplement all over the world due to its high …