Artificial intelligence to deep learning: machine intelligence approach for drug discovery

R Gupta, D Srivastava, M Sahu, S Tiwari, RK Ambasta… - Molecular …, 2021 - Springer
Drug designing and development is an important area of research for pharmaceutical
companies and chemical scientists. However, low efficacy, off-target delivery, time …

Advances in the development of new biomarkers for Alzheimer's disease

TO Klyucherev, P Olszewski, AA Shalimova… - Translational …, 2022 - Springer
Alzheimer's disease (AD) is a complex, heterogeneous, progressive disease and is the most
common type of neurodegenerative dementia. The prevalence of AD is expected to increase …

Neuropharmacological effects of quercetin: a literature-based review

MS Islam, C Quispe, R Hossain, MT Islam… - Frontiers in …, 2021 - frontiersin.org
Quercetin (QUR) is a natural bioactive flavonoid that has been lately very studied for its
beneficial properties in many pathologies. Its neuroprotective effects have been …

Impact of natural compounds on neurodegenerative disorders: from preclinical to pharmacotherapeutics

M Sharifi-Rad, C Lankatillake, DA Dias… - Journal of Clinical …, 2020 - mdpi.com
Among the major neurodegenerative disorders (NDDs), Alzheimer's disease (AD) and
Parkinson's disease (PD), are a huge socioeconomic burden. Over many centuries, people …

PPARγ/PGC1α signaling as a potential therapeutic target for mitochondrial biogenesis in neurodegenerative disorders

S Jamwal, JK Blackburn, JD Elsworth - Pharmacology & Therapeutics, 2021 - Elsevier
Neurodegenerative diseases represent some of the most devastating neurological
disorders, characterized by progressive loss of the structure and function of neurons. Current …

Computational/in silico methods in drug target and lead prediction

FE Agamah, GK Mazandu, R Hassan… - Briefings in …, 2020 - academic.oup.com
Drug-like compounds are most of the time denied approval and use owing to the
unexpected clinical side effects and cross-reactivity observed during clinical trials. These …

Dysfunctional mitochondria and mitophagy as drivers of Alzheimer's disease pathogenesis

A Chakravorty, CT Jetto, R Manjithaya - Frontiers in aging …, 2019 - frontiersin.org
Neurons are highly specialized post-mitotic cells that are inherently dependent on
mitochondria owing to their high bioenergetic demand. Mitochondrial dysfunction is …

Anthocyanins and their metabolites as therapeutic agents for neurodegenerative disease

AN Winter, PC Bickford - Antioxidants, 2019 - mdpi.com
Neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, and
amyotrophic lateral sclerosis (ALS), are characterized by the death of neurons within specific …

Bacopa monnieri, a Neuroprotective Lead in Alzheimer Disease: A Review on Its Properties, Mechanisms of Action, and Preclinical and Clinical Studies

AS Abdul Manap, S Vijayabalan… - Drug target …, 2019 - journals.sagepub.com
Alzheimer disease is a neurodegenerative disease that is signified by cognitive decline,
memory loss, and erratic behavior. Till date, no cure for Alzheimer exists and the current …

Beneficial effects of spirulina consumption on brain health

T Trotta, C Porro, A Cianciulli, MA Panaro - Nutrients, 2022 - mdpi.com
Spirulina is a microscopic, filamentous cyanobacterium that grows in alkaline water bodies.
It is extensively utilized as a nutraceutical food supplement all over the world due to its high …