Parental care influences development across mammals. In humans such influences include
effects on phenotypes, such as stress reactivity, which determine individual differences in …

The genome is programmed by the epigenome. Two of the fundamental components of the
epigenome are chromatin structure and covalent modification of the DNA molecule itself by …

The urokinase plasminogen activator (uPA) system (uPAS) consists of the uPA, its cognate
receptor (uPAR) and two specific inhibitors, the plasminogen activator inhibitor 1 (PAI-1) and …

BACKGROUND: Epigenetic mechanisms may be involved in the reprogramming of gene
expression in response to stressful stimuli. This investigation determined whether epigenetic …

Protocadherins constitute the largest subgroup in the cadherin superfamily of cell adhesion
molecules. Their major functions are poorly understood, although some are implicated in …

While specific genes are hypermethylated in the genome of cancer cells, overall
methylcytosine content is often decreased as a consequence of hypomethylation affecting …

Valproate (VPA) 1 has been used for decades in the treatment of epilepsy, and is also
effective as a mood stabilizer and in migraine therapy. It has been shown that VPA is also a …

Background: Epigenetic alterations are common in prostate cancer, yet how these
modifications contribute to carcinogenesis is poorly understood. We investigated whether …

RECK is a novel tumour suppressor gene that negatively regulates matrix
metalloproteinases (MMPs) and inhibits tumour invasion, angiogenesis and metastasis. In …

Despite our detailed characterization of the human genome at the level of the primary DNA
sequence, we are still far from understanding the molecular events underlying phenotypic …