Next-generation sequencing has revealed that more than 50% of human cancers harbour
mutations in enzymes that are involved in chromatin organization. Tumour cells not only are …

This year is the tenth anniversary of the publication in this journal of a model suggesting the
existence of'tumour progenitor genes'. These genes are epigenetically disrupted at the …

PM2. 5 particles in air pollution have been widely considered associated with respiratory
and cardiovascular diseases. Recent studies have shown that PM2. 5 can also cause …

Epigenetic phenomena in animals and plants are mediated by DNA methylation and stable
chromatin modifications. There has been considerable interest in whether environmental …

ABSTRACT DNA methylation is an epigenetic modification critical to normal genome
regulation and development. The vitamin folate is a key source of the one carbon group …

Amyotrophic lateral sclerosis (ALS) is the most common motor neuron disease in adults and
is characterized by neurodegeneration of motor neurons in the brain and spinal cord. The …

Derived from the term exposure, the exposome is an omic-scale characterization of the
nongenetic drivers of health and disease. With the genome, it defines the phenome of an …

The concept of 'lifestyle'includes different factors such as nutrition, behavior, stress, physical
activity, working habits, smoking and alcohol consumption. Increasing evidence shows that …

For several exposures, it has been proved that chemicals can alter epigenetic marks, and
that the same or similar epigenetic alterations can be found in patients with the disease of …

Epigenetics investigates heritable changes in gene expression that occur without changes
in DNA sequence. Several epigenetic mechanisms, including DNA methylation and histone …